含三氟甲基茚满化合物核磁共振谱研究

Investigation on Spectra of Indane Compounds Containing Trifluoromethyl by ~1H NMR and ^(13)C NMR Methods

含三氟甲基茚满化合物因其独特的理化性质和生物活性在众多领域得到广泛应用。本文报道了八个含三氟甲基茚满骨架化合物的核磁共振波谱~1H NMR,^(13)C NMR及DEPT 135。研究发现在所报道的该类化合物的^(13)C NMR谱图中,三氟甲基碳原子、与CF3直接连接的季碳原子以及与该季碳相邻的叔碳原子均裂分为规律的四重峰:中间高两边低;两个稠环桥头碳原子较其它芳碳原子处于更低场。在~1H NMR中,芳环上氢原子化学位移也是规律呈现。

Compounds containing trifluoromethyl and indanone are applicated in many fields because of their unique properties of physics and chemistry as well as excellent bioactivities. Herein,1H NMR,13 C NMR,and DEPT 135 spectra methods were used to investigate eight indane compounds containing trifluoromethyl. The carbon atom of trifluoromethyl,the quaternary carbon atom directly connects with trifluoromethyl and the other two tertiary carbon atoms adjacent to the quaternary carbon atom were all split into quartet in their13 C NMR spectra,and the two bridge carbon atoms in the fused rings were in low field than other aromatic carbon atoms. In1 H NMR spectra,the spectra of the hydrogen atoms being on the tertiary carbon atoms were also in regular pattern.