Graves眼病患者生活质量及眼病特异性生活质量的相关性

Relationship between the Health-related Life Quality and Graves′Ophthalmopathy Quality of Life in Graves' Ophthalmopathy Patients

目的评估Graves眼病(GO)患者的生活质量与眼病活动度、甲状腺自身抗体等的相关性。方法以SF-36量表及眼病特异性生活质量量表(GO-QOL)调查44例GO患者的生活质量评分,检测患者的甲状腺功能、相关抗体水平及疾病活动度评分。结果年龄>45岁的GO患者SF-36评分、GO-QOL评分显著低于年龄≤45岁的患者(P<0.05)。促甲状腺激素受体抗体(TRAb)>10 IU/m L的患者GO-QOL评分及其中的社会心理评分低于TRAb≤10 IU/m L的患者(P<0.05)。GO眼病活动度评分≥3分的患者SF-36评分和GO-QOL评分均显著低于眼病活动度评分<3分的患者(均P<0.01)。结论 GO患者眼病特异性的生活质量降低,降低程度与年龄、TRAb水平和眼病活动度相关。

Objective To study the relationship between the health-related quality dlife and Graves＇ ophthalmopathy quality of life （GO-QOL） in Graves＇ ophthalmopathy （GO） patients. Methods A total of 44 GO patients were recruited for the study and investigated with SF-36 and GO-QOL questionnaires. In addition, the thyroid function and related antibodies were also detected. Results The scores of SF-36 and GO-QOL were higher in the patients over 45 years than those under 45 years （P 〈 0.05 ）. GO-QOL score was lower in the patients with thyroid stimulating hormone recep- tor anfbody higher than 10 IU/mL （P 〈 0.05 ）. The scores of SF- 36 and GO-QOL were obviously higher in the patients who had a clinical activity score above 3 （P 〈 0.01 ）. Conclusion GO-QOL is a better and more specific questionnaire for GO patients.