慢性阻塞性肺疾病患者血清IL-6和黏着斑激酶水平检测临床意义

Significance of the Detecting IL-6 and FAK in Chronic Obstructive Pulmonary Disease

目的探讨慢性阻塞性肺疾病（COPD）患者检测血清IL-6和粘着斑激酶（FAK）水平的意义。方法选取COPD患者120例，对照组100例健康人群，通过酶联免疫吸附法（ELISA）检测血清IL-6和FAK水平。结果对照组和CC）PD各分级组间血尿酸、胆固醇和三酰甘油差异均无统计学意义（F=0．891～1．254，均P〉0．05），而FAK和IL-6水平比较差异有统计学意义（F-10．451～25．387，均P〈0．05）。COPDⅠ～Ⅳ级IL-6水平有升高的趋势，但各分级组间IL-6水平差异无统计学意义（t=0．098～0．145，均P〉0．05）。COPDⅠ～Ⅳ级FAK水平差异有统计学意义（t=33．541～55．612，均P〈0．05）。IL-6和FAK存在显著的正相关（r=0．881）。结论检测血清FAK可反映cOPD患者严重程度，且它是呼吸道平滑肌细胞增殖的靶标。

Objective To discuss on the significance of detection IIz6 and FAK in chronic obstructive pulmonary disease （COPD）. Methods Chosed 120 patients with suspected COPD and 100 cases as control group and detected IL-6 and FAK level by ELISA method. Results There were no statistical difference among UA,TC and TG level between COPD and control group （F= 0.891 - 1. 254, P〉0.05）. However IL-6 and FAK level had statistical difference between COPD and control group （F= 10. 451-25. 387 ,P〈0.05）. There was a increased tendency of IL-6 level from Ⅰ phase to Ⅳ phase,but no sta- tistical difference （t=0. 098-0. 145 ,P〉0.05）. There was statistical difference of FAK level from Ⅰ phase to Ⅳ phase （t= 33. 541-55. 612,P〈0.05）. IL-6 level was positively related to FAK level （r= -0. 881）. Conclusion FAK level in serum was detected in order to diagnose the serious degree of COPD. It can be a new indicator for smooth muscle cell proliferation of respiratory tract.