依达拉奉联合神经节苷脂对急性脑梗死患者血清BDNF、NGF和神经功能缺损的影响

Effects of Edaravone and Ganglioside on BDNF,NGF and Neurologic Impairment during the Treatment of Acute Cerebral Infarction

目的:研究依达拉奉联合神经节苷脂对急性脑梗死患者血清中BDNF、NGF含量变化与神经功能缺损的影响。方法:将120例急性脑梗死患者随机分为对照组和治疗组,对照组给予常规治疗,治疗组给予依达拉奉联合单唾液酸四己糖神经节苷脂治疗。对比两组患者治疗前和治疗后血清BDNF、NGF的含量和治疗后NHISS评分。结果:两组治疗后治疗组的NIHSS评分显著低于对照组(P<0.05)。治疗后治疗组的血清BDNF和NGF水平均显著高于对照组(P<0.05)。通过相关性分析显示NIHSS评分与BDNF和NGF含量之间存在显著负相关关系。结论:依达拉奉联合神经节苷脂可以改善急性脑梗死患者神经功能,与BDNF和NGF水平增高有关。

Objective:To investigate the effects of edaravone and ganglioside on the changes of BDNF and NGF levels and neurological impairment in acute cerebral infarction patients.Methods:120 patients with acute cerebral infarction were randomly divided into control group and treatment group.The control group was given routine treatment,the treatment group was given edaravone and ganglioside.The contents of BDNF and NGF and the NHISS score was compared between two groups before and after treatment.Results:The NIHSS score and levels of BDNF and NGF of the treatment group were significantly higher than those of the control group(P<0.05).The correlation analysis showed a significant negative correlation between NIHSS score and the content of BDNF and NGF.Conclusion:The treatment of acute cerebral infarction patients with edaravone and ganglioside can improve neurological function,and it was related to the increase of the levels of BDNF and NGF.