G-CSF动员造血干细胞机制研究进展

Research progress on the hematopoietic stem cell mobilization mechanism of G-CSF

人类粒细胞集落刺激因子(granulocyte colony-stimulating factor,G-CSF)是临床上广泛应用的细胞因子之一,最早用于治疗中性粒细胞减少症,降低癌症患者化疗后的死亡率。在临床应用中发现,其可以有效地动员骨髓中造血干细胞进入外周血,目前是临床上最常用的造血干细胞动员剂。介绍了G-CSF的生物学特性,并详细阐述了G-CSF动员造血干细胞的机制,为临床上G-CSF提高动员效率、减少副作用,以及为新型造血干细胞动员剂的开发提供理论基础。

G-CSF has been widely used in clinical, and it is not only used to treat neutropenia, but also used to reduce the mortality of cancer patients after chemotherapy. What＇s more, G-CSF is the most widely used hematopoietic stem cell （HSC） mobilization agent at present. The review introduced the biology of G-CSF, and focused on the HSC mobilization mechanism of G-CSF. To explore the exact mechanism is necessary to improve the efficiency of G-CSF mobilization, and to provide a theoretical basis for the development of new hematopoietic stem cell mobilization agents in the future.