摘要
目的：通过对儿童糖尿病（DM）患者资料的分析,探讨儿童DM的临床特征。方法：收集住院的37例DM患儿的临床表现、实验室检查、治疗转归等资料,分析儿童DM的类型、发病年龄、并发糖尿病酮症酸中毒（DKA）情况及DM相关抗体的变化。结果：37例DM患儿中,1型糖尿病（T1DM）32例（86.5%）,2型糖尿病（T2DM）4例（10.8%）,新生儿糖尿病（NDM）1例,T1DM的发病率高于T2DM（P〈0.05）;随着年龄的增长,DM发病率逐渐升高（χ^2=12.25,P〈0.05）;发病前有感染病史者比无感染病史者DKA的发病率高（P〈0.05）;T1DM患儿较非T1DM患儿C肽明显下降（P〈0.05）;T1DM患儿糖尿病自身抗体阳性,其中谷氨酸脱羧酶抗体（GAD-Ab）的敏感性最高（63.7%）。结论：T1DM是儿童DM的主要类型,DKA是儿童T1DM患者就诊的重要原因。
Objective： To investigate the clinical characteristics of juvenile diabetes mellitus（ DM）by analyzing clinical data. Methods： Clinical data of 37 cases of DM patients were collected and analyzed,the clinical manifestations（ medical history,symptom,physical examination）,laboratory and auxiliary examination,treatment method. Results： Among the 37 cases,Type Ⅰ diabetes（ T1DM） 32cases（ 86. 5%）,type Ⅱ diabetes（ T2DM） 4 cases（ 10. 8%）,and 1 cases of neonatal diabetes（ NDM）. T1 DM incidence rate was higher than T2DM（ P〈0. 05）; with the development of age,DM incidence rate increased as well（ χ~2= 12. 25,P〈0. 05）; the incidence rate of diabetic ketoacidosis（ DKA） for patients with infection history was higher than those with none（ P〈0. 05）; C peptide of T1 DM patients significantly decreased than non-T1 DM patients（ P〈0. 05）; T1 DM patients were measured diabetes autoantibodies,glutamic acid decarboxylase antibody（ GAD） positive rate was63. 7%. Conclusions： T1 DM was the major type of juvenile DM,while DKA is the essential factor for T1 DM patients.
出处
《贵阳医学院学报》
CAS
2016年第5期600-602,共3页
Journal of Guiyang Medical College
关键词
儿童
糖尿病
发病率
C肽
自身抗体
糖尿病酮症酸中毒
juvenile
diabetes mellitus
incidence rate
C peptide
autoantibody
clinical analysis
diabetic ketoacidosis
