参芪地黄汤对难治性肾病综合征患者肾功能的影响

The Effects of ShenQi DiHuang Tang on Renal Function of the Patients with Refractory Nephrotic Syndrome

目的:探讨参芪地黄汤对难治性肾病综合征患者肾功能的影响。方法:将150例患者随机分为观察组和对照组各75例。对照组给予对症处理及标准激素治疗;观察组在对照组基础上给予中药参芪地黄汤治疗,观察并记录2组患者治疗前后尿白蛋白量、内生肌酐清除率、尿素氮、血肌酐、血浆白蛋白等肾功能变化情况、中医证候积分情况及临床疗效和不良反应的发生情况。结果:尿白蛋白量、内生肌酐清除率、尿素氮、血肌酐、血浆白蛋白含量2组均较治疗前改善,差异有统计学意义(P<0.05),观察组改善更明显(P<0.05)。中医证候积分治疗后2组均降低(P<0.05);观察组降低更明显(P<0.05)。总有效率观察组为88.00%,对照组为65.30%,2组比较差异有统计学意义(P<0.05)。不良反应发生率观察组为6.67%,对照组为20.00%,,2组比较差异有统计学意义(P<0.05)。结论:参芪地黄汤治疗难治性肾病综合征,可改善患者肾功能,提高临床疗效,降低药物不良反应。

Objective： To explore the effects of ShenQi DiHuang Tang on renal function of the patients with refractory nephrotic syndrome. Methods： All 150 patients were randomly allocated to the observation group and the control group, 75 cases each group. The control group accepted corresponding therapy and standard hormone; the observation group took ShenQi DiHuang Tang on the foundation of the control group accepted. The changes of renal function including urinary albumin, endogenous creatinine clearance rate, usea nitrogen, serum creatinine, serum albumin and others, TCM symptome scales, clinical effects and the incidence of adverse reaction of both groups were observed and recorded. Results： The contents of urinary albumin, endogenous creatinine clearance rate, usea nitrogen, serum creatinine and serum albumin in both groups improved after treating compared with before treating obviously, and the difference had statistical meaning （P〈0.05）, the improvement of the observation group was more obvious （P〈0.05）. TCM symptom scales decreased significantly in both groups after treating （P〈0.05）; and the decrease of the observation group was more significant （P〈0.05）. Total effective rate of the observation group was 88.00%, higher than 65.30% of the control group, and the difference indicated statistical meaning （P〈0.05）. The incidence of adverse reaction of the observation group was 6.67%, lower than 20.00% of the control group, and the difference presented statistical meaning （P〈0.05）. Conclusion： ShenQi DiHuang Tang in treating of the patients with refractory nephrotic syndrome could improve renal function and clinical effects, decrease the incidence of drug adverse reaction.