儿童肾病综合征血小板参数与肾损害的分析

Correlation analysis of platelet relevant parameters and renal function damage in children with nephroticsyndrome

目的探讨儿童肾病综合征（NS）的血小板相关参数与。肾功能损害的关系。方法选择168例NS患者作为观察组，根据估算肾小球滤过率（eGFR）分期分为3组，选健康儿童100例为对照组。检测各组血常规、肝肾功能等，采用SPSS21．0软件进行统计分析。结果①观察组患儿与对照组比较，血小板总数（PLT）f（407．38±114．53）×10^9／L：（312．44±120．98）×10^9/L升高，血小板平均容积（MPV）[（9．36±0．83）fl：（9．62±0．88）f1]降低，差异有统计学意义（P〈0．05）；②PLT、MPV、血小板分布宽度（PDW）在肾功能3个分期比较差异无统计学意义（P〉0．05）。结论儿童NS患者的PLT、MPV较健康儿童升高。

Objective To investigate the correlation between platelet relevant parameters and renal function damage in children with nephrotic syndrome （NS）. Methods 168 NS patients were selected as observation group, divided into three groups according to eGFR level, and 100 healthy children were selected as control group. The blood routine, biomedical function of liver and kidney were detected. Data was analyzed by SPSS 21.0. Results （1）The levels of PLT, mean platelet volume （MPV） of observation group were higher than those of control group [（407.38±114.53）x109/L vs.（312.44±120.98）x 109/L, （9.36±0.83）fl vs.（9.62±0.88） fl; P〈0.05]. （2）There were no statistically significant differences in the levels of PLT, MPV, platelet distribution width （PDW） among NS patients with three renal function stages （P〉0.05）. Conclusion PLT, MPV are higher in children with NS compared with healthy children.