溃疡性结肠炎患儿的粪钙卫蛋白和血清白介素-2水平及其临床意义

Levels of fecal calprotectin and serum interleukin-2 in children with ulcerative colitis and its clinical significance

目的分析溃疡性结肠炎(UC)患儿粪便中钙卫蛋白(FCP)和血清白介素-2(IL-2)水平及其在评估UC活动性及病情严重程度中的临床意义。方法选择23例UC缓解期患儿、41例UC活动期患儿及20例单纯腹泻患儿,检测其FCP和血清IL-2的水平,同时对活动期UC患儿进行肠镜检查,进行内镜分级及临床严重程度评估。结果 UC患儿中位FCP水平为451.8μg/g,显著高于单纯腹泻患儿的34.6μg/g(P<0.05),活动期UC患儿、缓解期UC患儿及单纯腹泻患的FCP水平依次降低(P<0.05);UC患儿中位IL-2水平为213.0 ng/L,低于单纯腹泻患儿的349.2 ng/L(P<0.05),活动期UC患儿、缓解期UC患儿及单纯腹泻患的FCP水平依次升高(P<0.05)。64例UC患儿的Mayo评分与FCP水平呈正相关(P<0.05),与IL-2水平呈负相关(P<0.05)。在活动期UC患儿中,FCP水平与Mayo评分、临床严重程度以及内镜下分级呈正相关性(P<0.05),而IL-2与Mayo评分、临床病情分度与内镜下分级负相关性(P<0.01),FCP与IL-2呈负相关性(P<0.05)。结论检测FCP和IL-2水平有助于判断患儿活动性和病情严重程度。

Objective To investigate the levels of fecal calprotectin（ FCP） and serum interleukin-2（ IL-2） in children with ulcerative colitis（ UC）,and its clinical significance for evaluating the activity and severity of UC. Methods Twenty-three children in the remission stage of UC,41 children with active UC and 20 children with diarrhea alone were enrolled. The levels of FCP and serum IL-2 were detected in all children. For children with active UC,the enteroscopy was conducted,then the endoscopic grading and clinical severity were evaluated. Results The median level of FCP in the children with UC was 451. 8 μg / g,and was significantly higher than that in the children with diarrhea alone（ 34. 6 μg / g,P〈0. 05）. The level of FCP decreased in the order of the children with active UC,the children in the remission stage of UC and the children with diarrhea alone（ P〈0.05）. The median level of IL-2 in the children with UC was 213.0 ng/L,and was significantly lower than that in the children with diarrhea alone（ 349.2 ng/L,P〈0.05）. The level of IL-2 increased in the order of the children with active UC,the children in the remission stage of UC and the children with diarrhea alone（ P〈0. 05）. In the 64 children with UC,the Mayo score positively correlated with the FCP level（ P〈0. 05）,and negatively correlated with the IL-2 level（ P〈0. 05）. For the children with active UC,the FCP level positively correlated with the Mayo score,disease severity and endoscopic grading（ P〈0. 05）,but the IL-2 level negatively correlated with the Mayo score,disease severity and endoscopic grading（ P〈0. 01）,and the FCP level negatively correlated with IL-2（ P〈0. 05）. Conclusion The detection of FCP and IL-2 levels is helpful for evaluating the activity and severity of UC.