^(99)Tc^m-MDP全身骨显像诊断肺癌骨转移的临床价值

The Clinical Value of ^(99)Tc^m-MDP Whole Body Bone Imaging in Diagnosing Bone Metastasis of Lung Cancer

目的探讨肺癌骨转移临床诊断中99Tcm-MDP全身骨显像的诊断价值,以便评估患者的临床分期。方法对113例病理确诊为肺癌的患者均行99Tcm-MDP全身骨显像、血钙、碱性磷酸酶检查。通过99Tcm-MDP全身骨显像与高钙血症、碱性磷酸酶升高联合诊断骨转移的准确性进行统计学比较,并判断骨转移在不同病理类型肺癌患者中的发生几率是否相同。结果99Tcm-MDP全身骨显像诊断肺癌骨转移的灵敏度(92.7%),特异性(83.2%)、准确性(85.7%)。肺癌发生骨转移的总体几率为36.7%,肺腺癌较其他类型肺癌骨转移发生的几率高(P<0.01)。结论99Tcm-MDP全身骨显像的高灵敏度,对诊断肺癌患者骨转移有着重要的临床意义。

Objective To discuss the clinical value of whole body bone imaging on lung cancer bone metastases diagnosis, so as to evaluate the staging of lung cancer patients. Methods A total of 113 cases of patients diagnosed with lung cancer received whole body imaging, alkaline phosphatase and blood calcium examination. Bone metastasis probability of lung cancer was assessed based on different pathological types. Accuracy rates of bone metastases was compared by whole body bone imaging and suspicious bone metastasis factors （Including one or several items in ostalgia, alkaline phosphatase rising and bypercalcemia）. Results The occurrence rate of lung cancer bone metastasis is 36.7%, and the bone metastasis occurrence rate of adenocarcinoma of lung is higher than that of squamous cell lung carcinoma （ P 〈 0.01 ）. Whole body Imaging diagnose of lung cancer bone metastases had sensitivity （92. 7% ）, specificity （83. 2% ） and accuracy （85.7 % ）. Conclusion 99TCm-MDP whole body imaging is a highly sensitive tool to review whole body bone. Lung cancer patients are recommended to receive routine whole body bone imaging.