有精神症状的功能性消化不良患者血浆obestatin、ghrelin水平的变化及其与精神症状的相关性

Variation of plasma obestatin and ghrelin levels in functional dyspepsia patients with mental symptoms and its relationship with the scores of anxiety and depression

[目的]探讨有精神症状的功能性消化不良(functional dyspepsia,FD)患者的肥胖抑制素(obestatin)及胃促生长素(ghrelin)的水平变化及其与焦虑/抑郁状态的相关性。[方法]采用ELISA法测定41例伴有精神症状的FD患者(FD组)和40例健康体检者(对照组)的血浆obestatin和ghrelin水平。[结果]FD组血浆obestatin水平较对照组明显升高(P<0.05);FD组血浆ghrelin水平较对照组明显降低(P<0.01);血浆obestatin水平与HAMA及HAMD评分均呈正相关(r=0.131,P<0.05;r=0.106,P<0.05);血浆ghrelin水平与HAMA及HAMD评分均呈负相关(r=-0.428,P<0.01;r=-0.462,P<0.01)。[结论]有精神症状的FD患者的血浆obestatin水平高于对照组,且与焦虑/抑郁状态呈正相关;ghrelin水平低于对照组,且与焦虑/抑郁状态呈负相关。

[Objective]To investigate the variation of plasma obestatin,ghrelin levels in functional dys- pepsia（FD） patients with mental symptoms and its relationship with the score of anxiety/depression. [Methods]Plasma obestatin,ghrelin levels in 41 cases of FD patients and 40 cases of healthy volunteers were measured by ELISA. Hamilton anxiety/ depression scales were used to score anxiety and depression in the FD group and the control group. [Results]Plasma obestatin levels in FD group were significantly higher than the control group（P〈0.05） ; plasma ghrelin levels of FD group were significantly lower than the control group（P〈0.01）. A positive correlation（r=0. 131 ,P〈0.05;r=0. 106 ,P〈0.05）was identified among the Scores for HAMA, HAMD and plasma obestatin levels;a negative correlation（r=--0. 428,P〈 0.01 ;r=--0. 462, P〈0.01）was identified among the Scores for HAMA, HAMD and plasma ghrelin lev- els. In FD patients with moderate degree of anxiety, severe depression and anxiety with depression, plasma obestatin levels were significantly higher than the control group（P〈0.05）, while plasma ghrelin levels were significantly lower than the control group（P〈0.05）. [Conclusion]Plasma obestatin levels in FD pa- tients with anxiety and depression were significantly higher than the control group,and have a positive cor- relation with the Scores for HAMA, HAMD. Plasma ghrelin levels in FD patients with anxiety and depres- sion are significantly lower than the control group,and have a negative correlation with the Scores for HA- MA, HAMD.