重症感染患儿抗生素相关性腹泻临床分析

Clinical analysis of antibiotic-associated diarrhea in severe infection children

目的探讨重症感染患儿抗生素相关性腹泻(AAD)的发病及抗生素使用情况。方法回顾性分析166例重症感染患儿的临床资料,总结和探讨重症感染患儿AAD的发病率、抗生素使用情况。结果 166例患儿中,发生AAD 92例(55.4%);引发AAD的常见抗生素为头孢菌素。AAD患儿年龄、抗生素使用时间、种类、基础疾病与非AAD患儿比较差异均有统计学意义(P<0.05)。结论重症感染患儿AAD发病率较高,与年龄、抗生素使用时间、种类、基础疾病相关。

ObjectiveTo investigate morbidity and antibiotics application condition for antibiotic-associated diarrhea （AAD） in severe infection children.MethodsClinical data of 166 severe infection children were retrospectively analyzed. Summary and investigation were made on morbidity of AAD in severe infection children and antibiotics application condition.ResultsAmong the 166 children, 92 cases had AAD （55.4%）. Common antibiotics inducing AAD was cephalosporin. The differences of age, antibiotics application time, types, and underlying disease between children with and without AAD all had statistical significance （P〈0.05）. ConclusionMorbidity rate of AAD is high in severe infection children, and it is correlated with age, antibiotics application time, types, and underlying disease.