喜炎平注射液联合更昔洛韦对小儿病毒性肺炎炎症因子的影响

Effect of Xiyanping injection combined with ganciclovir on inflammatory factors of viral pneumonia in children

目的观察喜炎平注射液联合更昔洛韦对小儿病毒性肺炎炎症因子的影响。方法选取2013年7月~2014年7月在本院接受治疗的小儿病毒性肺炎患者120例,按随机数表法分成观察组60例和对照组60例。对照组患者单纯使用更昔洛韦进行治疗,对观察组患者使用喜炎平注射液联合更昔洛韦进行治疗,对治疗进行7 d后对2组患者的治疗效果、咳嗽消失时间、退热时间、肺部啰音消失时间以及C-反应蛋白、TNF-α、IL-6、IL-8等炎症因子水平进行观察和比较并观察患者药物不良反应的出现情况。结果观察组与对照组相比较,咳嗽消失时间、退热时间、肺部啰音消失时间更短,治疗总有效率为93.33%,高于对照组的68.33%,2组比较差异有统计学意义（P〈0.05）。进行治疗后2组患者的炎症因子水平均低于治疗前,观察组患者下降幅度明显大于对照组,差异具有统计学意义（P〈0.05）。观察组患者X线片情况较对照组得到较大改善,差异有统计学意义（P〈0.05）。2组患者均极少出现不良反应。结论喜炎平注射液联合更昔洛韦治疗小儿病毒性肺炎的临床疗效优于单纯更昔洛韦治疗,能更加有效的降低患者体内炎症因子的水平,且极少出现不良反应,是一种安全有效的治疗方法。

Objective To observe the impact of Xiyanping injection combined with ganciclovir on inflammatory factors in viral pneumonia in children. Methods Totally 120 pediatric patients with viral pneumonia were selected from July 2013 to July 2014 in our hospital, and randomly divided into an observation group（60 patients） and the other 60 in the control group. The control group were given ganciclovir. The observation group were given Xiyanping injection combined with ganciclovir. The treatment effect, cough disappeared time, cooling time, pulmonary rale disappearing time and C-reactive protein, TNF-α, IL-6, IL-8 and other inflammatory cytokine levels were observed after the 7-day treatment. The emergence of adverse reactions was compared between the 2 groups. Results The cough disappearing time, cooling time, and pulmonary rale disappearing time of the observation group were earlier and shorter than those of the control group. The total effective rate of the observation group was 93.33%, higher than 68.33% in the control group, with significant difference（P 〈 0.05）. The inflammatory cytokine level before the treatment in the 2 groups was lower than that after the treatment. The decrease of the observation group was higher than that of the control group, with significant difference（P 〈 0.05）. The X ray film of the observation group was significantly improved compared with the control group（P 〈 0.05）. Few adverse reactions happened. Conclusion The clinical efficacy of Xiyanping injection combined with ganciclovir on viral pneumonia in children is better than that of ganciclovir alone and can more effectively reduce the level of inflammatory with few adverse reactions. It is safe and effective.