利培酮治疗首发精神分裂症停药前用药时间与临床疗效的关系

Relationship between TTD and clinical efficacy of Risperidone for the first episode schizophrenia

目的探讨利培酮治疗首发精神分裂症患者停药前用药时间（time to discontinuation,TTD）与临床疗效的关系。方法选择2013年6月~2015年5月在我院治疗的首发精神分裂症患者160例的临床资料进行回顾性分析,所有患者均采用利培酮治疗。根据患者停药前用药时间分为〈2周组、2周组、4组、6周组、8周组、12周组。比较不同停药前用药时间与患者临床疗效的关系。结果治疗满12周组治疗后PANSS评分最低,其次为8周组,6周组、4周组和2周组,〈2周组治疗后PANSS评分最高,各组间比较差异有统计学意义（P〈0.01）。各组临床疗效比较,12周组最好,其次为8周组,6周组,4周组,2周组,〈2周组临床疗效最差,各组间比较差异有统计学意义（P〈0.01）。结论利培酮治疗的首发精神分裂症患者停药前用药时间越短,疗效越差。

Objective To discuss relationship between TTD and clinical efficacy of Risperidone for the first episode schizophrenia. Methods Clinical data of 160 cases with first episode schizophrenia treated with Risperidone were respectively analyzed. All cases were divided into 6 groups ：〈 2 weeks,2 weeks group,4 weeks group,6 weeks group,8 weeks group and 12 weeks group according to TTD. Relationship between TTD and clinical efficacy was analyzed. Results PANSS score of 12 weeks group was the lowest,followed by 8 weeks group,6 weeks group,4 weeks group and 2 weeks group,and the group of 〈 2 weeks was highest,which showed significant differences among different groups（P〈0.01）. Clinical efficacy of 12 weeks group was the best,followed by 8 weeks group,6 weeks group,4 weeks group and 2 weeks group,and the group of 〈 2 weeks was the worst,which showed significant differences among different groups（P〈0.01）. Conclusion The shorter TTD of Risperidone for the first episode schizophrenia is,the worse the clinical efficacyis.