葡萄籽提取物预防阿尔茨海默病的研究进展

Research progress of grape seed extract for the prevention of Alzheimer's Dementia

阿尔茨海默病目前已成为世界上继心脏病、肿瘤和脑卒中之后的第四大死因,其发病机制十分复杂,至今尚未研究清楚。目前所有治疗阿尔茨海默病的药物只能有限地减缓病情的恶化,而无法真正治愈。最新研究表明葡萄籽提取物能够预防一种可导致阿尔茨海默病认知障碍的淀粉类蛋白质分子在脑内的形成。本文对阿尔茨海默病的定义、发病机理和葡萄籽提取物在预防和治疗阿尔茨海默病的应用及研究进展作一综述,为以后利用葡萄籽提取物研发预防或治疗阿尔茨海默病药剂提供理论参考。

AIzheimer＇ s dementia has become the fourth cause of death in the world,after heart disease,cancer and stroke,the pathogenesis is very complex and has not been studied clearly.All drugs in the treatment of Alzheimer＇ s dementia can only be limited to slow down the deterioration of the condition at present, but can＇ t cure the disease. The latest research suggests grape seed extract can prevent the formation of a starch protein molecules which can lead to cognitive impairment of Alzheimer＇ s dementia in the brain.This paper makes a review on the definition and the pathogenesis of Alzheimer＇ s dementia,and grape seed extract in the application and research of prevention and treatment of Alzheimer＇ s dementia, which provide a theoretical reference for the future development of prevention or treatment of Alzheimer＇ s dementia by grape seed extract.