Hp感染与胃息肉和痘疮样胃炎的发病关系分析

Correlation analysis between Helicobacter pylori infection and gastric polyp and varioliform gastritis

目的 分析并探讨幽门螺杆菌（Hp）与胃息肉和痘疮样胃炎的发病关系。方法 选取2014年1月-2015年12月我院收治的胃息肉、痘疮样胃炎患者各130例进行研究,另选130例消化性溃疡患者作为对照分析。所有患者均行13C-UBT呼气试验,对三组患者Hp感染情况进行统计和分析。结果痘疮样胃炎组Hp感染率67.69%,高于消化性溃疡组的54.62%（χ^2=4.679,P=0.031）和胃息肉组的39.23%（χ^2=21.163,P=0.000）,消化性溃疡组感染率高于胃息肉组（χ^2=6.177,P=0.013）。胃息肉组增生性息肉Hp感染率最高,为47.95%,与炎性息肉Hp感染率（26.32%）比较差异有统计学意义（χ^2=4.850,P=0.028）。痘疮样胃炎组中肠化生Hp感染率最高,为76.67%,但各病理分型之间的Hp感染率比较无显著性差异（P〉0.05）。结论 Hp感染与痘疮样胃炎的发生紧密关联,与胃息肉发生无明显关联性,但与胃息肉病理类型相关,其中增生性息肉Hp感染率显著高于炎性息肉。

Objective To analyze and investigate the relationship between Helicobacter pylori （Hp） infection and gastric polyp and varioliform gastritis. Methods From January 2014 to December 2015, 130 patients with gastric polyp and 130 patients with varioliform gastritis in our hospital were involved in the study, while 130 patients with peptic ulcer were selected as the control analysis. 13C-UBT breath test was performed on all of the patients, and Hp infection in each group was statistically analyzed. Results The Hp infection rate in varioliform gastritis group was 67.69%, which was higher than that in the peptic ulcer group of 54.62% （χ^2=4.679, P=0.031） and gastric polyp group of 39.23% （χ^2= 21.163, P=0.000）, the Hp infection rate of peptic ulcer group was significantly higher than that of gastric polyp group （χ^2=6.177, P=0.013）. The Hp infection rate of hyperplastic polyp in the gastric polyp group was g7.95%, which was significantly higher than that of inflammatory polyp of 26.32%（χ^2=4.850, P=0.028）.The Hp infection rate of intestinal metaplasia was 76.67%, which was highest in varioliform gastritis group. However, there was no statistical difference among the different types of varioliform gastritis group（P〉0.05）. Conclusion Hp infection is closely associated with varioliform gastritis, but there is no significant correlation between Hp infection and gastric polyp. However, Hp infection is related to gastric polyp type, and Hp infection rate of hyperplastic polyp is notably higher than that of inflammatory polyp.