摘要
以藤黄酸为原料,通过7步反应合成了具有抗肿瘤活性化合物藤酰苷并对其抗肿瘤活性进行了初步筛选。目标产物结构经1 H NMR和ESI-MS确证,体外细胞实验结果显示藤酰苷对多种肿瘤细胞有效。
Using as starting material gambogic acid, the anti-tumor active compund cygareinia glycosides was synthesized through a seven-steps reaction, and its antitumor activity was tested. The structure of cygareinia glycosides has been verified by 1HNMR and ESI-MS. In vitro experiments showed that cyga-reinia glycosides was effective on cancer cells.
出处
《化学世界》
CAS
CSCD
2016年第7期415-419,共5页
Chemical World
基金
"十一五"新药创制重大专项(No.2009ZX09103-030)
关键词
藤酰苷
藤黄酸
合成
cygareinia glycosides
gambogacid
synthesis
