骨标志物检测的临床研究

Clinical study of bone markers detection

目的研究分析骨标志物对骨质疏松症患者的诊断、治疗及疗效观察中所起的作用,预防骨质疏松性骨折的发生,提高患者的生活质量。方法选取本院65例符合诊断标准的骨质疏松症患者,另选35例中老年（女性为绝经后）健康体检者为健康对照组,采用化学发光法对二组受检人群进行骨标志物测定,对检测结果进行比较。结果 100例受检人群中健康体检者35例,骨质疏松症患者65例,男42例,女58例,年龄55-80岁,平均年龄65.7岁。骨质疏松症患者骨标志物检测结果明显高于健康体检人群,具有统计学意义（P〈0.05）。骨质疏松症患者治疗后检测结果比治疗前检测结果有明显下降,具有统计学意义（P〈0.05）。结论骨标志物能动态反映全身骨代谢的变化,对骨质疏松症的早期诊断、治疗监控和预后评估均有较大的临床意义。

Objective To analyze the bone markers in diagnosis,treatment and prognosis role in the prevention of osteoporos-isfractures and improving the life quality of patients. Methods A total of 65 cases of osteoporosis proven by clinical diagnostic cri-teria from the hospital were included in the study,35 healthy persons with middle age and aged （female after menopause） served as the control group. Chemiluminescence assay was used to detect the bone markers,and the results were compared. Results Base-line demographic data of 100 subjects：35 healthy people,65 patients with osteoporosis;42 males and 58 females;55-80 years old,mean age 65.7 years old. The level of bone markers in the group with osteoporosis were significantly higher than that in healthy group （P〈0.05）. Test results of osteoporosis patients after treatment significantly declined compared with before treatment （P〈0.05）. Conclusion Bone markers can dynamically reflect changes in bone metabolism in the body,which is significantly impor-tant in early diagnosis,prognosis and treatment monitor of osteoporosis.