加味四二汤对早期2型糖尿病肾病患者UAL,SOD,MDA的影响

Effect of Jiawei Sier Decoction on UAL,SOD,and MDA Levels in Patients with Early Type 2 Diabetic Nephropathy

目的:观察加味四二汤对早期2型糖尿病肾病患者的尿白蛋白(UAL),血清超氧化物歧化酶(SOD),丙二醛(MDA)的影响及临床疗效,并探讨其机制。方法:将90例诊断为早期2型糖尿病肾病、中医辨证为气阴两虚证的患者按随机数表法分为加味四二汤组、银杏达莫注射液组和常规组,各30例,3组均予以2型糖尿病常规治疗,在此基础上加味四二汤组予以加味四二汤联合卡托普利治疗,银杏达莫注射液组予以银杏达莫注射液联合卡托普利治疗,治疗周期为4周,治疗前后检测患者UAL,SOD,MDA的变化,对患者中医证候进行评分。结果:治疗后加味四二汤组、银杏达莫注射液组UAL,MDA显著低于治疗前(P<0.01),SOD显著高于治疗前(P<0.01),中医证候积分显著低于治疗前(P<0.01)。与常规组比较,加味四二汤组、银杏达莫注射液组治疗后UAL,MDA显著降低(P<0.01),SOD显著增高(P<0.01),中医证候积分显著降低(P<0.01)。与银杏达莫注射液组比较,治疗后加味四二汤组UAL,MDA显著降低(P<0.01),SOD显著增高(P<0.01),中医证候积分显著降低(P<0.01)。结论:加味四二汤治疗早期2型糖尿病肾病能显著改善患者的临床症状,减少患者UAL,升高血清SOD,降低血清MDA,这可能与其抗氧化应激有关。

Objective ： To observe the effect of Jiawei Sier decoction for urinary albumin （UAL） , serum superoxide dismutase （SOD）, and malondialdehyde （MDA） levels in early type 2 diabetic nephropathy patients, and investigate its clinical efficacy. Method： The 90 cases of early type 2 diabetic nephropathy with traditional Chinese medicine （TCM） syndrome differentiation of Qi and Yin deficiency were randomly divided into Jiawei Sier decoction group （30 cases） , gingko dipyridolum injection group （30 cases） , and conventional treatment group （30 cases） according to random number table method. The patients in all 3 groups received conventional therapy for type 2 diabetes, based on the above conventional therapy, patients in modified Jiawei Sier decoction group also received Jiawei Sier decoction treatment combined with captopril therapy, patients in gingko dipyridolum injection group also received ginkgo dipyridolum injection combined with captopril therapy. All patients were treated for 4 weeks. UAL, SOD and MDA levels were detected, and the TCM symptom scores were observed both before and after treatment. Result： UAL and MDA levels in Jiawei Sier decoction group and gingko dipyridolum injection group after treatment were significantly lower than those before treatment （P 〈 0.01 ） , SOD level was significantly higher than that before treatment （P 〈0.01 ） , and TCM symptom scores were significantly lower than those before treatment （P 〈 0.01 ）. As compared with conventional treatment group, UAL and MDA levels in Jiawei Sier decoction group and gingko dipyridolum injection group were significantly lower, while SOD level was higher after treatment （P 〈 0.01 ） , the TCM symptom scores were significantly lower in Jiawei Sier decoction group and gingko dipyridolum injection group （P 〈 0.01 ）. Conclusion： Jiawei Sier decoction treatment can obviously improve the clinical symptoms, reduce UAL and MDA levels and increase SOD level in serum for patients with early type 2 diabetic nephropathy, this may be related to its resistance to oxidative stress.