慢性阻塞性肺病炎性因子(CRP、TNF-α、IL-6)与冠脉造影Gensini评分相关性研究

The study of correlation between the inflammatory factors( CRP,TNF-α,IL-6) of chronic obstructive pulmonary disease and coronary angiography Gensini score

目的 研究慢性阻塞性肺病患者血清CRP、TNF-α、IL-6水平与冠脉造影Gensini评分相关性。方法 选择2010年5月-2011年7月我院收治的慢性阻塞性肺病患者98例,根据Gensini评分将其分为3组：轻度组（〈20分）57例,中度组（20-40分）16例,重度组（〉40分）25例,比较3组患者血清CRP、TNF-α、IL-6水平,并分析98例患者血清CRP、TNF-α、IL-6水平与其Gensini评分之间的相关性。结果 重度组患者CRP、TNF-α、IL-6水平均高于中度组和轻度组,同时中度组亦高于轻度组,差异有统计学意义（P〈0.05）。CRP、TNF-α、IL-6水平与Gensini评分呈正相关。结论慢性阻塞性肺病有促进冠状动脉粥样硬化发病的可能性。

Objective To study the correlation about the serum CRP, TNF- α, IL-6 levels of chronic obstructive pulmonary disease patients and coronary angiography Gensini score. Methods We selected 98 patients with chronic obstructive pulmonary disease in our hospital from May 2010 to October 2012. According to Gensini score, patients will be divided into 3 groups ： mild group （〈20） in 57 cases, moderate group （20 -40） in 16 cases, severe group （〉40） in 25 cases. We compared serum CRP, TNF- α, IL-6 level, and analysed the correlation between of the serum CRP, TNF-α, IL-6 level and Gensini score in 98 cases. Results The CRP,TNF- α , IL-6 of severe group were higher than those in moderate and mild group, moderate group was also higher than that of the mild group at the same time, the difference was statistically significant （ P 〈 0.05 ）. The CRP, TNF alpha, IL - 6 level and Gensini score were positively correlated. Conclusion Chronic obstructive pulmonary disease has the possibility of promoting coronary atherosclerotic disease.