射频消融联合聚桂醇注射治疗婴幼儿腮腺血管瘤的临床研究

Clinical study of radiofrequency ablation combined with lauromacrogol for the treatment of parotid gland hemangioma in infants

目的 探讨射频消融联合聚桂醇注射治疗婴幼儿腮腺血管瘤的临床效果.方法 117例腮腺血管瘤患儿随机分为实验组32例、对照组1共30例、对照组2共28例及对照组3共27例,实验组采用射频消融联合聚桂醇注射治疗,对照组1为单纯射频消融治疗,对照组2为单纯平阳霉素注射治疗,对照组3采用射频消融联合平阳霉素注射治疗,术后随访6 ～ 24个月,评估实验组与3组对照组疗效的差异.结果 实验组与对照组的治疗有效率比较,差异无统计学意义.对照组1患儿痊愈16例（53.3％）,其中9例治疗次数≥2次,术后创面破溃、消化道反应、肝功能损害各1例,高热5例.对照组2患儿痊愈17例（60.7％）,12例治疗次数≥2次,术后创面破溃3例、消化道反应9例、肝功能损害6例、高热5例.对照组3患儿痊愈21例（77.8％）,2例治疗次数≥2次,术后创面破溃2例、消化道反应6例、肝功能损害4例、高热4例.实验组患儿痊愈25例（78.1％）,4例治疗次数≥2次,与对照组1、2比较,差异有统计学意义（P＜0.05）;术后创面破溃2例、消化道反应及肝功能损害各1例,高热6例,与对照组2、3比较,差异有统计学意义（P＜0.05）.结论 射频消融联合聚桂醇注射治疗婴幼儿腮腺血管瘤效果确切,不良反应少.

Objective To investigate the clinical effect of radiofrequency ablation （RFA） combined with lauromacrogol for the treatment of parotid gland hemangioma in infants.Methods From Sep.2005 to Dec.2014,a total of 117 patients with parotid gland hemangioma were divided into observation group （n =32）,control group 1 （n =30）,control group 2 （n =28） and control group 3 （n =27）.The observation group was treated by RFA combined with lauromacrogol,while the control group 1 was treated by RFA only,the control group 2 was treated by pingyangmycin only,and the control group 3 received additional pingyangmycin based on RFA.All the patients were followed up for 6 to 24 months,and the clinical effects were observed in four groups.Results Control group 1：16 patients were cured （53.3%）,and the number of patients with ≥2 treatments was 9.There was 1 case with skin ulceration,1 with abdominal discomfort,1 with liver function damage and 1 with high fever.Control group 2：17 patients were cured（60.7%）,and number of patients with ≥2 treatments was 12.There were 3 cases with skin ulceration,9 with abdominal discomfort,6 with liver function damage and 5 with high fever.Control group 3：21 patients were cured（77.8%）,and number of patients with ≥2 treatments was 2.There were 2 cases with skin ulceration,6 with abdominal discomfort,4 with liver function damage and 4 with high fever.However,in observation group,25 patients were cured（78.1%） and number of patients with ≥ 2 treatments was 4,which were significantly different from that in control group 1 or control group 2 （P 〈0.05）.And the difference in postoperative adverse reactions between observation group and control group 2 or control group 3 was also of significance （2 with skin ulceration,1 with abdominal discomfort,1 with liver function damage and 6 with high fever,P 〈 0.05）.Conclusions Combined RFA and lauromacrogol has a good therapeutic effect on parotid gland hemangioma with relatively low adverse effect,so it deserves to be suggested and applied in clinical practice.