阿德福韦酯联合丹参片治疗慢性乙型肝炎肝纤维化的临床疗效

Clinical Efficacy of Adefovir Dipivoxil Combined with Danshen Tablets in the Treatment of Hepatic Fibrosis in Chronic Hepatitis B

目的 分析阿德福韦酯联合丹参片治疗慢性乙型肝炎肝纤维化的临床疗效。方法 选取我院2011年5月-2015年4月收治的78例慢性乙型肝炎肝纤维化患者作为本次研究的对象,采取随机数字表法将78例慢性乙型肝炎肝纤维化患者分为联合组（39例）和单独组（39例）,联合组患者采取阿德福韦酯联合丹参片治疗,单独组患者采取阿德福韦酯治疗。比较两组患者治疗前后的AST、ALT肝功能指标以及HA、LN、Ⅳ-C、PCⅢ肝纤维化指标变化情况。结果 联合组与单独组在治疗后AST、ALT肝功能指标以及HA、LN、Ⅳ-C、PCⅢ肝纤维化指标均出现了明显改善（P〈0.05）,且联合组改善情况明显优于单独组（P〈0.05）。结论 阿德福韦酯联合丹参片治疗慢性乙型肝炎肝纤维化具有良好的临床疗效。

Objective To analyze the clinical curative effect of the treatment of liver fibrosis in chronic hepatitis B of adefovir dipivoxil combined with Danshen tablets. Methods 78 cases of chronic hepatitis B with hepatic fibrosis in our hospital from May 2011 to April 2015 were selected as the subjects of this study. 78 patients with chronic hepatitis B were divided into combined group （39 cases） and single group （39 cases） by random number table. The combined group was treated with adefovir dipivoxil combined with Salvia miltiorrhiza, and the single group was treated with adefovir dipivoxil treatment. AST, ALT liver function index and HA, LN, Ⅳ -C, PC III liver fibrosis index changes of two groups before and after treatment were compared. Results Cmbined group and single group after treatment in AST, ALT of liver function index and HA, LN and IV-C, PC III liver fibrosis index appeared improved significantly （P〈0.05）, and the combined group improved significantly better than alone group （P〈0.05）. Conclusion Adefovir dipivoxil combined with Salvia miltiorrhiza has good clinical efficacy in the treatment of liver fibrosis in chronic hepatitis B.