卵巢癌化疗耐药的发生机制及应对措施

Mechanisms and Countermeasures of Resistance to Chemotherapy in Ovarian Cancer

卵巢癌是妇科恶性肿瘤中常见且病死率最高的疾病。长期以来卵巢癌治疗效果一直未能得到有效改善,且卵巢癌化疗药物耐药性的产生使卵巢癌的治疗更加困难。化疗耐药是卵巢癌治疗中的重大难题,其产生涉及一系列机制。前期发现药物作用靶点、DNA损伤修复系统、细胞凋亡调控多方面异常与化疗药物的耐药性有关,而近几年发现耐药性可分为靶前耐药、靶上耐药、靶后耐药及脱靶耐药,另外卵巢癌微环境的改变等促进了耐药性机制的研究。同时,耐药性的预测及应对,尤其是中医对耐药性的逆转得到了深入研究,促进了卵巢癌的有效治疗。

Ovarian cancer is a common gynecological malignant tumor with the highest mortality. The treatment ofovarian cancer has not been effectively improved for a long time, while the chemotherapy drug resistance has made it even moredifficult. Previous studies showed that the chemotherapy drug resistance was relevant with the abnormity of drug targets, DNAdamage repair system and apoptosis regulation. Recent studies suggest that drug resistance could be divided into pre-target, ontarget,post -target and off -target mechanism. In addition, there are many new findings which have promoted the study ofresistance mechanism, such as the changes in the microenvironment of ovarian cancer. In the meantime, the prediction andresponse of drug resistance, especially the reversal of drug resistance in traditional Chinese medicine, has been further studiedand improved the effective treatment of ovarian cancer.