新疆乌鲁木齐市新市区妇女生殖道人乳头瘤状病毒感染基因分型研究

Study on genotyping of genital tract HPV infection in women from Xinshi areas of Urumqi City,Xinjiang

目的探讨新疆乌鲁木齐市新市区HPV感染情况、型别分布、与宫颈病变的相关性。方法采用机会抽样方法对新疆乌鲁木齐市新市区1989名女性行高危型人乳头瘤状病毒（HPV）分型检测、液基细胞涂片，分析HPV感染情况、型别分布、与宫颈病变的相关性。结果新疆乌鲁木齐市新市区女性HPV阳性率为27．95％，高危型HPV感染率为19．36％。以HPV-16、18、58和56型HPV阳性者最多。新疆乌鲁木齐市新市区女性HPV检出率在≤30岁、〉30～40岁、〉40～50岁、〉50岁4个年龄段差异有高度统计学意义（P〈0．01），其中，〉30～40岁年龄组HPV感染率最高，多重感染在各年龄阶段差异无统计学意义（P〉0．05）。HSIL／宫颈癌患者HPV-16感染高于ASCUS／LSIL患者，差异有统计学意义（P〈0．05）。结论HPV分型检测对宫颈病变的早期诊断与预后有重要意义。HPV-16、18、58和56相关的感染与宫颈癌前病变关系密切，这在新疆地区疫苗的制备上有特殊及重大意义。

Objective To investigate the cervical human papillomavirus （HPV） infection, type distribution and the correlation with cervical lesions in the Xinshi areas of Urumqi City, Xinjiang. Methods Opportunity sampling method was used to investigate a total of 1989 women received liquid-based cytology test and I-IPV types test in Xinshi area of Urumqi City, Xinjiang. HPV infection, type distribution and the correlation with cervical lesions were analyzed. Results The positive rate of HPV was 27.95% in women of Xinshi areas in Urumqi City, Xinjiang. The detection rate of highrisk genotypes of HPV was 19.36%, genotypes of HPV-16, 18, 58, 56 were common in high-risk of HPV. The HPV positive rates of the different age groups （aged ≤ 30, 〉30-40, 〉40-50 and 〉50） was statistically significant （P 〈 0.01）; the HPV infection rate was the highest in 〉30-40 years old age group. There was no difference in multiple infections among different age groups （P 〉 0.05）. The HPV-16 infection rate in patients with HSIL/cervieal cancer was significantly higher than that in patients with ASCUS/LSIL（P 〈 0.05）. Conclusion HPV typing detection has important significance in the early diagnosis and prognosis of cervical lesions. HPV-16, 18, 58 and 56 related infections are closely related with precancerous lesions of uterine cervix. This has a special and significant meaning in the generation of the vaccine in Xinjiang.