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基底细胞样乳腺癌老年患者Ki-67表达与TopoⅡα、C-MYC基因的相关性 被引量:3

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摘要 目的探讨基底细胞样乳腺癌(BLBC)和非BLBC(NBLBC)癌组织中TopoⅡα、C-MYC基因扩增与Ki-67表达的关系。方法该院临床病理诊断中心经石蜡包埋的乳腺癌组织,其中100例BLBC癌组织、100例NBLBC癌组织,对照组选取100例同期周围正常乳腺组织。结果TopoⅡα与C-MYC基因改变类型主要为扩增与缺失,TopoⅡα、C-MYC和Ki-67在对照组表达不显著。100例BLBC病理组织中,TopoⅡα与C-MYC基因扩增分别为43例和51例,缺失分别为57例49例;Ki-67阳性76例,阴性24例;TopoⅡα、C-MYC基因扩增与Ki-67表达在Spearman等级相关分析中有统计学意义(P<0.05)。100例NBLBC病理组织中,TopoⅡα与C-MYC基因扩增分别为34例和43例,缺失66例和57例;Ki-67阴性16例,阳性84例;Spearman等级相关分析,TopoⅡα、C-MYC基因扩增与Ki-67表达相关(P<0.05),TopoⅡα与C-MYC基因扩增呈正相关(P<0.05)。与NBLBC比较,BLBC的TopoⅡα与C-MYC基因扩增略多。结论 TopoⅡα、C-MYC基因扩增与Ki-67相关。与NBLBC比较,BLBC癌组织的TopoⅡα、C-MYC基因扩增较多,TopoⅡα与C-MYC基因扩增可能参与乳腺癌的发生发展过程。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2016年第16期3988-3990,共3页 Chinese Journal of Gerontology
基金 齐齐哈尔市科技局指令性科研项目
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