炎性因子以及PCT用于鉴别诊断颅内感染的性质

Inflammatory factors and PCT for the differential diagnosis of the nature of intracranial infection

目的探讨炎性因子以及PCT对于鉴别诊断颅内感染的性质的临床价值。方法选取我院收治的30例化脓性脑膜炎患者作为A组,选取27例病毒性脑炎患者作为B组,另选取18例正常人群作为C组,比较各组脑脊液IL-6、IL-8以及血清PCT的浓度变化情况。结果3组患者的IL-6、IL-8以及TNF-ɑ比较差异有统计学意义(P<0.05),A组PCT水平明显高于C组及B组,差异有统计学意义(P<0.05),C组及B组之间PCT水平比较差异无统计学意义(P>0.05)。A组以及B组治疗后的脑脊液IL-6、IL-8以及TNF-ɑ水平均明显低于治疗前,A组治疗后的PCT水平明显下降,差异有统计学意义(P<0.05),B组患者治疗前后的PCT水平比较差异无统计学意义(P>0.05)。结论脑脊液IL-6、IL-8以及TNF-ɑ、PCT水平对于颅内感染的病情监测以及疗效评价等方面均有着十分重要的价值。

Objective To study the clinical value of inflammatory factors and PCT for the differential diagnosis of the nature of intracranial infection. Methods 30 patients with suppurative meningitis were selected from our hospital as the suppurative meningitis group; 27 patients with viral encephalitis were selected as viral encephalitis group; the other 18 cases of normal people were selected as control group. The levels of cerebrospinal fluid IL-6, IL-8 and the change of the concentration of serum PCT were compared between groups. Results The levels of IL-6, IL-8 and TNF-ɑ of the 3groups were significantly different（P0.05）. PCT level of the suppurative meningitis group was obviously higher than that of control group and viral encephalitis group（P 〈0.05）, while the PCT levels of the control group and the viral encephalitis group had no significant difference（P0.05）. After treatment, the cerebrospinal fluid IL-6, IL-8 and TNF-ɑlevels were significantly lower than those before treatment in the suppurative meningitis and viral encephalitis group. The PCT level of the suppurative meningitis group was significantly decreased after treatment（P 〈0.05）,but showed no significant change in the viral encephalitis patients（P 〈0.05）. Conclusion The CSF levels of IL-6, IL-8, TNF-ɑ and PCT could be used for the evaluation of curative effect and monitoring of intracranial infection.