基因芯片技术在人体锥虫生物学特性研究方面的进展

Application of DNA Microarray Technology in Human Trypanosomiasis Research

随着分子生物学技术的迅速发展,基因芯片技术在生物学和医学领域,以其高通量的特点展示出强大的优势。在众多人体血液原虫疾病中,锥虫病一直是国际关注的焦点,基因芯片技术为锥虫基因组、虫体与宿主的相互作用的研究,以及疫苗的筛选和药物的研制提供了技术手段。本文就基因芯片在人体布氏锥虫(Trypanosoma brucei)和克氏锥虫(T.cruzi)研究中的应用作一概述。

With the rapid development of molecular biological techniques, DNA microarray has shown great advantage in biology and medicine as it allows high-throughput measurement of various biological parameters. Trypanosomiasis remains the focus among numerous human blood parasitic diseases. The DNA microarray is a useful technique for studying the trypanosome genome and parasite-host interaction, as well as for vaccine screening and drug development. This review gives an update on the application of DNA mieroarray in human research on Trypanosoma brueei and Trypanosoma cruzi.