维生素K1辅助治疗百日咳综合征的疗效分析

Efficacy of vitamin K1 in the adjuvant treatment of pertussis syndrome

目的：观察维生素 K1辅助治疗百日咳综合征患儿痉挛性咳嗽的效果及对住院时间的影响。方法将87例百日咳综合征患儿采用数字表法随机分成对照组41例、治疗组46例，对照组予以抗感染、呼吸道支持、解痉平喘、祛痰等治疗；治疗组在观察组治疗基础上加用维生素 K1治疗，比较两组痉挛性咳嗽持续时间及住院时间。结果治疗组痉挛性咳嗽消失时间、住院时间分别为（7．22±1．33）d、（9．52±1．84）d，对照组分别为（15．51±2．73）d、（18．71±3．30）d，两组差异均有统计学意义（t ＝－18．310、－16．269，均 P ＜0．01）。治疗组显效18例，有效25例，无效3例，总有效率为93．5％；对照组显效7例，有效23例，无效11例，总有效率为73．1％。两组总有效率差异有统计学有意义（χ^2＝4．285，P ＜0．05）。结论维生素 K1对缓解小儿痉挛性咳嗽有明显效果，可缩短百日咳综合征患儿痉挛性咳嗽持续时间及住院时间，提高临床疗效。

Objective To investigate the effects of vitamin K1 in the adjuvant treatment of spasmodic cough in pertussis syndrome children,and its impacts on length of hospital stay.Methods 87 pertussis syndrome children were randomly divided into two groups,among which 41 cases in the control group were treated with the therapies such as anti -infection,respiratory support,antispasmodic,expectorant et al,while 46 cases in the treatment group were treated additionally with vitamin K1 on the basis of the control group.Then compared the duration and hospital stay of the two groups with spasmodic cough.Results The disappeared time of spasmodic cough in the treatment group was （7.22 ±1.33）d and hospital stay was （9.52 ±1.84）d,which in the control group were （15.51 ±2.73）d,（18.71 ± 3.30）d respectively,and there were statistically significant differences（t =-18.310,-16.269,all P 〈0.01）.In the treatment group,the total effective rate was 93.5%,there were 18 cases with markedly effective,25 cases with effective and 3 cases with ineffective.Correspondingly,there were 7 cases markedly effective,23 cases effective, 11 cases ineffective,and total efficiency rate was only 73.1% in the control group,the difference was statistically significant（χ^2 =4.285,P 〈0.05 ）.Conclusion Vitamin K1 to alleviate spasmodic cough in children has a significant effect,which can reduce the duration of the cough time and hospital stay in pertussis syndrome children, and also can improve the clinical effect.