原发性醛固酮增多症病人NT-proBNP水平变化及临床意义

Changes and Clinical Significance of Serum N-terminal Pro-B-type Natriuretic Peptide in Patients with Primary Aldosteronism

目的探讨原发性醛固酮增多症病人N末端脑钠肽原(NT-proBNP)水平变化及临床意义。方法选取2015年1月—2016年1月在湖北省荆州市中医医院诊断并且治疗的原发性醛固酮增多症病人40例(病例组),另外选取在我院体检的健康志愿者40名(正常组)。测定两组血浆NT-proBNP水平,观察病例组病人在手术切除后NT-proBNP水平变化。结果正常组、病例组血浆NT-proBNP水平分别为(55.21±21.32)pg/mL、(466.43±131.21)pg/mL,病例组NT-proBNP水平高于正常组(P<0.05);病例组术前、术后血浆NT-proBNP水平分别为(466.43±131.21)pg/mL、(65.21±11.32)pg/mL,术后较术前明显降低(P<0.05)。结论NT-proBNP在评估原发性醛固酮增多症病人的严重程度和预后方面具有重要意义。

Objective To investigate the levels changes and its clinical significance of plasma N terminal pro brain natriuretic peptide （ NT proBNP）in patients with primary aldosteronism. Methods In this study, we retrospective review 40 patients with primaryaldosteronism and 40 normal individuals from January, 2015 to January, 2016. We measured the level of plasma NT proBNP in patients and the normal individuals. What is more, we also compared the levels change between the before and after operation.Results The levels of plasma NT proBNP were 55.21 pg/mL±21.32 pg/mL in patients, 466.43 pg/mL±131.21 pg/mL in normal individuals,respectively（ P 〈0.05） . The levels of plasma NT proBNP were 466.43 pg/mL±131.21 pg/mL, 65.21 pg/mL±11.32 pg/mL before andafter operation, respectively（ P 〈0.05） . Conclusion Elevated levels of plasma NT proBNP in patients with primary aldosteronismwill help evaluate the servility of the patients. What is more, NT proBNP is easily to test , can be an hopeful index for primary aldo -steronism. But the level of NT proBNP can be affected by many factors. It will need more high quality studies.