低氧条件下低氧诱导因子1α/miR-210调节回路对肿瘤能量代谢及血管生成的调控

Regulation of HIF-1α/miR-210 loop on energy metabolism and angiogenesis in hypoxic condition

低氧诱导因子1(HIF-1)是低氧下肿瘤细胞信号通路的核心调控因子,研究表明与HIF-1生物学调控功能(血管生成、能量代谢、细胞增殖、细胞凋亡和侵袭转移等)起协同作用的是mi R-210,mi R-210受低氧及HIF-1α调控而表达上调,反之上调的mi R-210又增强HIF-1α分子稳定性,由此两者共同构成HIF-1α/mi R-210调节回路,对肿瘤细胞多种生物学行为进行精确调控,本文对HIF-1α/mi R-210调节肿瘤能量代谢及血管生成两方面做一简要综述。

HIF-1 is a core regulatory factor in hypoxic signaling pathways of tumor. Studies show that miR-210 plays a synergistic role in the HIF-1-mediated biological activities including angiogenesis, energy metabolism, cell proliferation, apoptosis, invasion and metastasis. In hypoxia miR-210 is up-regulated by HIF-1α and miR-210 in turn enhances the stability of HIF-1α, thus the two together constitute the HIF-1α/miR-210 regulation loop and regulate various biological behaviors of tumor cells. In this review, we focus on the regulation of tumor energy metabolism and angiogenesis by HIF-1 /miR-210.