泛素?蛋白酶体途径在精子生成中的作用

The role of ubiquitin-proteasome pathway in spermatogenesis

泛素?蛋白酶体途径(Ubiquitin–proteasome pathway,UPP)是真核细胞内蛋白质主要降解途径,通过调节蛋白质相互作用、蛋白活性、蛋白定位及信号转导,进而在细胞周期进程、细胞凋亡、应激反应及机体生长发育等过程发挥重要作用。研究表明,UPP在人和动物精子生成中的顶体生物合成及精子尾部形成过程起着关键的调控作用,精子变态过程中UPP调控异常导致精子畸形及精子活力降低,并引发少精子症、不育及睾丸肿瘤等生殖系统疾病。本文综述了UPP在动物精子生成过程中的信号传导及调节机制,以期为后续相关研究提供参考。

Ubiquitin-proteasome pathway （UPP） is the main pathway of protein degradation in eukaryotic cells. The UPP plays very important roles in cell cycle progression, apoptosis, stress response and growth and development through regulating protein interaction, protein activity, protein localization and signal transduction. Previous studies have shown that the UPP is essential for regulating acrosome and tail biogenesis during spermatogenesis in human and animals. The dysreg-ulation of UPP during spermatogenesis results in sperm deformity and reduced sperm motility and leads to reproductive system diseases such as oligospermatism, infertility and testicular tumors. In this review, we summarized the signal trans-duction and regulation mechanism of UPP in spermatogenesis, which may provide references for future studies.