单倍体干细胞研究进展

Progress in haploid stem cell research

单倍体干细胞是一种全新的人工建立的细胞类型。在中国科学院"干细胞与再生医学研究"战略性科技先导专项的支持下,我国科学家在哺乳动物单倍体干细胞的建立和应用上取得了一系列重要进展,极大地丰富了单倍体干细胞类型,建立了多种新的基于单倍体干细胞的遗传修饰和辅助生殖技术,展示了单倍体干细胞可能为生殖生物学、发育生物学、遗传学和进化生物学带来的重要应用前景。主要对我国科学家在单倍体干细胞领域取得的进展进行介绍。

The haploid stem cell is a novel type of artificially established cells. Supported by the Stem Cell and Regenerative Medicine Strategic Priority Research Program of the Chinese Academy of Sciences, Chinese scientists have made a serial of achievements on derivation and application of haploid stem cells, which enriched the haploid stem cell types, established multiple new techniques for genome modification and assisted reproduction, and brought great prospects for studies of reproduction, development, genetics and evolution. Here we review the progress on haploid stem cell research in past five years supported by the Strategic Priority Research Program.