奥曲肽与生长抑素治疗肝硬化合并上消化道出血疗效对比研究

Octreotide and propranolol in treatment of liver cirrhosis combined with upper gastrointestinal hemorrhage and effects on hemodynamics

目的:探讨生长抑素与奥曲肽对肝硬化上消化道出血患者的临床治疗效果及对血流动力学影响。方法:172例肝硬化上消化道出血患者随机分为对照组与观察组,每组为86例,观察组实施奥曲肽治疗,对照组采用生长抑素治疗。结果:对照组治疗后总有效率为74.42%,观察组93.02%,两组差异有统计学意义(P<0.05);治疗后两组肝功能和肝纤维化指标均下降,但观察者明显高于对照组,差异有统计学意义(P<0.05);治疗后观察组门静脉血流量、脾静脉血流量明显较对照组低,差异有统计学意义(P<0.05)。结论:肝硬化上消化道出血采取奥曲肽治疗安全性高,可有效改善血流动力学。

Objective：To study the efficacy of propranolol combined with octreotide on cirrhosis with upper digestive tract hemorrhage clinical treatment effect and hemodynamic effects.Methods：172cases of liver cirrhosis on digestive tract hemorrhage patients as the research object,randomly divided into for the control group and the observation group each group of 86 cases and observation group implementation of octreotide combined with propranolol treatment,the control group only treated with octreotide and of treatment in the two groups curative effect and hemodynamics were observed.Results：In the control group after treatment,the total effective rate was 74.42%,the observation group 93.02%,there was significant difference between two groups（P〈0.05）;before the treatment,the two groups had no significant difference in the liver function and liver fibrosis index comparison（P〈0.05）;the two groups after treatment,the liver function and liver fibrosis the indicators were lower,but the observer decrease was significantly higher than that in that in the control group,the difference was statistically significant（P〈0.05）.after the treatment,the observation group blood flow of portal vein,splenic vein blood flow was significantly lower than that in the control group,the difference was statistically significant（P〈0.05）.Conclusion：Liver cirrhosis with upper gastrointestinal bleeding is taken the safety of propranolol combined with octreotide in the treatment of the high,can effectively improve hemodynamics,is worthy of promotion.