PUFA抗炎保护大脑功能研究进展

Research Progress of PUFA Protecting the Brain Function via Anti-inflammatory Actions

大脑内环境的稳定是维护神经细胞和神经胶质细胞正常结构和功能的基础,也是实现大脑正常功能的必要条件。脑组织的炎症(inflammation)是影响大脑内环境稳定的重要因素。大量研究显示:脑组织中,多不饱和脂肪酸(polysaturated fatty acid,PUFA)可通过抗炎、抗氧化等作用,保护大脑的正常功能。尤其近来发现:特殊促愈合介质(specialized pro-resolving mediators,SPMs)是一类具有特殊抗炎作用的生物活性分子,可能是n-3 PUFA抗炎的重要分子基础,并通过脑组织中的神经胶质细胞,发挥抗炎作用。这已成为PUFA抗炎功能研究的一个重要方向。

The homeostasis of local brain environment is essential for the normal structure and function of neuron and glia cell. The inflammation in brain affects the brain internal environment homeostasis. Various studies have indicated that polyunsaturated fatty acid （PUFA） could reduce the oxidative stress and inflammation in brain tissue, and protect brain function. Recent studies have demonstrated that specialized pro-resolving mediators （SPMs） are important anti-inflammatory bioactive molecules, which may be the mechanism foundation of n-3 PUFA＇ brain protective effects. The anti-inflammatory effects of SPMs in glia cells have attracted lots of attentions in PUFA functional research, so that it has become an important research direction.