放射性^(125)I粒子植入联合动脉化疗栓塞治疗乏血供肝癌的临床研究

Radioactive seed ^(125)I implantation combined with transcatheter arterial chemoembolization(TACE) in treating poor blood supply hepatocarcinoma

目的探讨经导管动脉化疗栓塞(TACE)联合放射性125I粒子植入治疗乏血供肝癌的疗效。方法回顾性分析68例乏血供肝癌患者的临床资料,根据患者治疗方式分为两组:联合组(TACE联合125I粒子植入治疗,35例)、对照组(单纯TACE治疗,33例)。比较两组术后总体有效率、血清甲胎蛋白下降率(AFP)、肿瘤进展率、术后肝功能变化等指标。结果联合治疗组术后12个月总有效率[(CR+PR)/(CR+PR+SD+PD)],进展率[PD/(CR+PR+SD+PD)]和AFP下降率分别为75.8%,9.1%,60.6%;对照组分别为32.0%,56.0%,28.0%,两组差异有统计学意义(P<0.05)。结论 TACE联合放射性125I粒子植入治疗乏血供肝癌疗效可能优于单纯TACE治疗。

Objective To investigate the value of the combined treatment of transcatheter arterial chemoembolization （TACE）and radi-oactive seed 125 I implantation for poor blood supply hepatocarcinoma.Methods Clinical data of 68 cases of poor blood supply hepato-carcinoma were retrospectively analyzed,which were assigned into two groups：combination therapy group （treated by TACE in combina-tion with seed 125 I implantation,n =35）and control group （treated by TACE alone,n =33）,according to therapy methods.Postopera-tive total effective rate,reduction rate of AFP,tumor progression rate and postoperative liver function were detected in the two groups. Results Total effective rate,tumor progression rate and reduction rate of AFP in 12 months after interventional therapy in combination therapy group and control group were 75.8% vs 32.0%,9.1% vs 56.0% and 60.6 % vs 28.0%,respectively.There were significant differences in these data between combination therapy group and control group （P 〈0.05）.Conclusions Combination therapy of TA-CE and radioactive seed 125 I implantation may be more efficient to treat poor blood supply hepatocarcinoma than therapy of TACE alone.