期刊文献+

肝脏肿瘤不同调强放疗计划的剂量学对比 被引量:4

Dosimetric comparison study on different intensity- modulated radiation therapy planning for liver tumor
下载PDF
导出
摘要 目的:应用放射治疗计划系统比较四种肝癌动态调强放疗计划的靶区及肝组织的剂量学分布,探讨最佳的布野模式。方法:共研究15例行调强放疗的肝脏肿瘤患者,对每例患者分别制定两种共面野计划和两种非共面野计划。评估的剂量学参数包括:PTV的适形指数(CI)和均匀指数(HI),正常肝脏接受≥40、30、20、10体积的百分数(V40、V30、V20、V10),正常肝脏的平均剂量(MDTNL)以及脊髓和肾脏的剂量分布。结果:非共面野调强计划相对于共面调强计划而言,可在不影响靶区剂量分布的情况下,明显降低正常肝脏组织的平均剂量,对肝脏的V10、V20、V30具有明显优势,而对肝脏V40,脊髓和肾脏的剂量分布无明显影响。结论:在肝脏肿瘤的放射治疗过程中,非共面野调强计划可能在减少肝组织的受照剂量,降低放射性肝病发生的危险性上具有一定优势。 Objective: To select reasonable treatment methods for liver tumor,the dose distribution by three- dimensional treatment planning system( TPS) for target area and normal liver around liver tumor in four intensity modulated radiation therapy plans were assessed. Methods: Selected 15 patients with liver tumor,Four IMRT plans were designed for each patient: Two coplanar intensity modulated radiation therapy plans( plan A,plan B) and two non-coplanar intensity modulated radiation therapy plans( plan C,plan D). The same physical objective function was applied for the same patient in four plans. Compared the dose distribution of the target area and the mean dose,V10,V20,V30,V40 for the normal liver. Results: Compared to IMRT,non- coplanar intensity modulated radiation therapy( NC-IMRT) significantly reduced the volume of normal liver V10,V20,V30 and mean dose of the normal liver. Without obvious variations in CI,HI,spinal cord and kidney. However,the volume of liver V40 did not significantly change. Conclusion: During radiotherapy for patients with liver tumor,NC- IMRT might reduced the irradiated dose of the normal liver,which would allow the risk of radiation induced liver disease( RILD).
出处 《现代肿瘤医学》 CAS 2016年第22期3600-3602,共3页 Journal of Modern Oncology
关键词 肝脏肿瘤 调强放射治疗 非共面 剂量学 liver tumor intensity-modulated radiation therapy non-coplanar dosimetry
  • 引文网络
  • 相关文献

参考文献2

二级参考文献17

  • 1陈旭明,姚升宇,许奕,徐冰,赵国旗.非共面野在脑胶质瘤调强放射治疗中的剂量学优势[J].中国医学物理学杂志,2011,28(2):2475-2477. 被引量:14
  • 2Lee EK, Fox T, Crocker I. Simultaneous beam geometry and intensity map optimization in intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys,2006,64:301-320.
  • 3Bedford JL, Henrys AJ, Dearnaley DP, et al. Treatment planning evaluation of non-coplanar techniques for conformal radiotherapy of the prostate. Radiother Oncol,2005,75:287-292.
  • 4Darby S, McGale P, Peto R, et al. Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer nation wide cohort study of 90000 Swedish women. BMJ, 2003, 326 : 256-257.
  • 5王绿化,张红星,陈东福.第六篇胸部肿瘤第二章肺癌[A]//殷蔚伯,余子豪,许国镇,等.肿瘤放射治疗学(第四版)[M].北京:中国协和医科大学出版社,2008:578-609.
  • 6Yorke ED, Jackson A, Rosenzweig KE, et al. Correlation ofdosimetric factors and radiation pneumonitis for non-small cell lungcancer patients in a recently completed dose escalation study [ J].Int J Radiat Oncol Biol Phys, 2005,63 (3 ) : 672-682. DOI: 10.1016/j. ijrobp. 2005.03.026.
  • 7Paddick I. A simple scoring ratio to index the conformity of radio-surgical treatment plans. Technical note [J]. J Neurosurq,2000,93 ( 3 ): 219-222. DOI: 10. 3171/jns. 2000. 93. supplement3. 0219.
  • 8Murshed H,Liu HH,Liao Z,et al. Dose and volume reduction fornormal lung using intensity-modulated radiotherapy for advanced-stage non-small-cell lung cancer [ J ]. Int J Radiat OncolBiolPhys,2004,58(4) :1258-1267. D01:10.1016/j. ijrobp. 2003.09.086.
  • 9Willner J,Jost A,Baier K,et al. A little to a lot or a lot to a little.An analysis of pneumonitis risk from dose-volume histogramparameters of the lung in patient with lung cancer treated with 3-Dconformal radiotherapy [ J] . Strahlenther Onkol, 2003,179 ( 8 ):548-556.
  • 10Hernando ML, Marks LB, Bentel GC, et al. Radiation-inducedpulmonary toxicity : a dose-volume histogram analysis in 201patients with lung cancer [ J]. Int J Radiat Oncol Biol Phys,2001,51(3) :650-659. DOI: 10.1016/S0360-3016(01 )01685-6.

共引文献7

同被引文献35

引证文献4

二级引证文献16

;
使用帮助 返回顶部