乳化超声吸除术联合人工晶状体植入治疗糖尿病性白内障的机制研究

Mechanism of phacoemulsification combined with intraocular lens implantation for diabetic cataract treatment

目的:探究乳化超声吸除术联合人工晶状体植入治疗对糖尿病性白内障患者炎症因子、氧化应激反应和血液流变学的影响,为糖尿病性白内障患者的临床治疗提供相关帮助。方法:选取本院收治的160例糖尿病性白内障患者,按随机数字表法分为观察组和对照组,各80例,对照组采用常规治疗,观察组在常规治疗基础上给予乳化超声吸除术联合人工晶状体植入治疗。治疗前后检测各组患者炎症因子、氧化应激反应指标和血液流变学指标。结果:治疗前两组糖尿病性白内障患者炎症因子、氧化应激反应指标和血液流变学指标水平比较的差异无统计学意义(P>0.05)。与治疗前相比,两组患者经相关治疗后炎症因子白介素-2(IL-2)、白介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)显著升高(P<0.05);氧化应激反应指标过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、血液流变学指标全血黏度高切(WHV)、全血黏度中切(WMV)、血浆粘度(PV)显著降低(P<0.05);红细胞压积(PCV)和纤维蛋白原(FIB)变化不明显(P>0.05)。与治疗后对照组相比,观察组经治疗后MDA、炎症因子(IL-2、IL-6、hs-CRP和TNF-α)和血液流变学指标(WHV、WMV、PV)显著降低(P<0.05);氧化应激反应指标(CAT、SOD、GSH-Px)显著升高;PCV和FIB变化不明显(P>0.05)。结论:乳化超声吸除术联合人工晶状体植入显著改善糖尿病性白内障患者的炎症因子、氧化应激反应指标和血液流变学指标水平,对糖尿病性白内障患者的治疗具有十分重要的临床意义。

Objective：To observe the effects of phacoemulsification combined with intraocular lens implantation on inflammatory factors,oxidative stress reaction and the hemorheology in patients with diabetic cataract in order to find better treatments for patients with diabetic cataract.Methods：A total of 160 cases of diabetic cataract patients in our hospital were selected and randomly divided into observation group and control group,with 80 cases in each group.Control group was treated with conventional therapy,observation group was treated with phacoemulsification combined with intraocular lens implantationbased on conventional therapy,the changes of inflammatory factors,oxidative stress reaction and the hemorheology were detected before and after treatment.Results：Difference in inflammatory factors,oxidative stress reaction and the hemorheology between the two groups before treatment was not statistically significant（P〈0.05）.Inflammatory factors（IL-2,IL-6,hs-CRP and TNF-α）,MDA in both groups after treatment significantly increased compared with that before treatment.Oxidative stress reaction parameters（CAT、SOD、GSH-Px）,hemorheology parameters（WHV、WMV、PV）in both groups after treatment significantly decreased compared with that before treatment.PCV and FIB in two groups after treatment was not statistically significant compared with that before treatment（P〉0.05）.MDA,Inflammatory factors（IL-2,IL-6,hs-CRP and TNF-α）and hemorheology parameters（WHV、WMV、PV）in observation group after treatment decreased more significantly than that in control group,（P〈0.05）.oxidative stress reaction parameters（CAT、SOD、GSH-Px）in observation group after treatment increased more significantly than that in control group,（P〈0.05）.PCV and FIB had no significant changes（P〉0.05）.Conclusion：Phacoemulsification combined with intraocular lens implantation could improve inflammatory factors,oxidative stress reaction parameters and hemorheology parameters in diabetic cataract patients,and help clinical treatment of diabetic cataract patients.