钻孔引流联合阿托伐他汀治疗慢性硬膜下血肿60例临床观察

The clinical observation of drilling drainage combined with atorvastatin for 60 cases with chronic subdural hematoma

目的探讨钻孔引流加阿托伐他汀治疗慢性硬膜下血肿的临床疗效。方法将120例慢性硬膜下血肿患者均分为两组,各60例。2011年10月至2013年2月入院的为对照组,给予钻孔引流术治疗。2013年3月至2014年6月入院的为观察组,给予钻孔引流术加阿托伐他汀治疗。观察两组的患者治疗效果、ADL-Barthel评分、症状消失时间及不良反应发生情况。结果观察组治疗有效率为96.7%,明显高于对照组的80.0%(P<0.05)。治疗前,两组ADL-Barthel评分对比无统计学意义(P>0.05);治疗后,两组ADL-Barthel评分均明显改善,且观察组明显优于对照组(P<0.05)。观察组症状消失时间明显短于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论钻孔引流加阿托伐他汀治疗慢性硬膜下血肿的疗效显著,安全性较高。

Objective To investigate the clinical efficacy of drilling drainage combined with atorvastatin for patients with chronic subdural hematoma. Methods One hundred and twenty cases of patients with chronic subdural hematoma were divided into two groups, with 60 cases in each group. The control group was selected from October 2011 to February 2013 and given drilling drainage, while the observation group was selected from March 2013 to June 2014 and given drilling drainage combined with atorvastatin. The treatment efficacy, ADL-Barthel score, symptoms disappearing time and incidence rate of adverse reactions in the two groups were compared. Results The efficacy rate in the observation group was 96.7%, which was obviously higher than 80.0% in the control group （P〈0.05）. The ADL-Barthel scores in the two groups before treatment had no statistical significance （P〉O.05）. The ADL - Barthel score in two groups were significantly improved after treatment, and the ADL-Barthel score of the observation group was obviously better than that in the control group （P〈0.05）. The symptoms disappearing time in the observation group was significantly shorter than that in the control group （P〈0.05）. The incidence of adverse reactions in the two groups had no significant difference （P〉0.05）. Conclusion Drilling drainage combined with atorvastatin has a high safety and efficacy.