大理地区人群血清乙肝病毒标志物两对半的模式分布探讨

Analysis of serological infection modules of HBV markers in Dali population

目的探讨大理地区人群血清乙型肝炎病毒标志物"两对半"的模式分布情况,解释常用乙肝病毒血清学标志物的临床检测结果,使乙肝"两对半"标志物检测能更好地应用于临床。方法对8 303例住院患者采用化学发光免疫分析法检测血清HBV标志物,"1、2、3、4、5"分别代表HBs Ag、HBs Ab、HBe Ag、HBe Ab、HBc Ab。结果检出乙型肝炎血清学"两对半"定量模式15种,"1、2、3、4、5"阴性占47.30%,"2"阳性占16.90%,"2、5"阳性占12.50%,"2、4、5"阳性占12.10%,"1、4、5"阳性占4.62%,"5"阳性占3.06%,"4、5"阳性占1.73%,"1、3、5"阳性占0.98%。结论大理地区HBV感染率稍低于全国平均水平,HBs Ab阳性人群比例偏低,需进一步强化免疫,降低HBV感染率。

Objective To analyze the serological infection modules of hepatitis B virus in Dali,and to explain the results of HBV serological markers and to apply the markers correctly for clinicians to analyze HBV infection status. Methods The serum HBV markers were quantitatively detected by chemiluminescence immunoassay in 8 303 patients,and 1,2,3,4,and 5 represented the HBs Ag,HBs Ab,HBe Ag,HBe Ab and HBc Ab respectively. Results Fifteen serological infection modules of hepatitis B virus were found in which,＂1,2,3,4,5＂negative accounted for47. 3%,＂2＂positive accounted for 16. 9% ＂2,5＂positive accounted for 12. 5%,＂2,4,5＂positive accounted for12. 1%,＂1,4,5＂positive accounted for 4. 62%,＂5＂positive accounted for 3. 06%,＂4,5＂positive accounted for 1. 73% and ＂1,3,5＂positive accounted for 0. 97%. Conclusion The average positive rate of HBV is lower in Dali population than in China population.