女性下生殖道HPV感染与宫颈上皮内瘤变及宫颈癌关系的病理研究

Relation of female lower genital tract HPV infection and cervical intraepithelial neoplasia and cervical cancer

目的:探讨女性下生殖道高危型人乳头状瘤病毒(high risk human papillomavirus,HR-HPV)感染与宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)及宫颈癌的关系。方法:选择2013年2月-2015年4月我院收治的236例CIN及宫颈癌患者为观察组,进行下生殖道HPV(人乳头状瘤病毒)检测,分析CIN及宫颈癌与HPV感染的关系,并与对照组有宫颈炎但无CIN及宫颈癌的126例患者进行对比研究。结果:HRHPV感染率随着患者CIN的严重程度而升高,宫颈癌的HR-HPV感染率最高为91.89%,明显高于对照组差异具有统计学意义(P<0.05)。HR-HPV双重感染率以及HR-HPV多重感染率与单一HR-HPV患者的病毒感染率相比较高,差异具有统计学意义(P<0.05)。且患者随着病情的加重,单型、双重、多重HRHPV感染率从CINⅠ期、CINⅡ期、CINⅢ期呈递增趋势。结论 :HR-HPV感染及HR-HPV多重感染是导致宫颈上皮内瘤变及宫颈癌发生的重要诱因,对高危型HPV病毒的持续感染,及时的诊断并予以有效的治疗,能够阻滞癌前病变的发展,对于预防宫颈上皮内瘤变及宫颈癌,降低宫颈癌的死亡率具有重要临床意义。

Objective： To investigate the relationship between genital HPV infection and cervical intraepithelial neoplasia and cervical cancer in women. Methods： All 236 cases of CIN and cervical cancer patients were selected as observation group,with lower genital tract HPV（ human papilloma virus） detection,126 cervicitis patients were controls. Results： HR- HPV infection in patients with the severity of CIN increased,HR- HPV infection of cervical cancer was 91. 89 %（ P〈0. 05）. HR- HPV infection and double infection rates of multiple HR- HPV infection in patients with a single HR- HPV was higher（ P〈0. 05）. Conclusion： HR- HPV infection and multiple HR- HPV infection is a major cause of cervical intraepithelial neoplasia and cervical cancer.