自噬及其在脑缺血再灌注损伤中作用机制

Mechanism of Action of Autophagy on the Cerebral Ischemia-Reperfusion Injury

自噬是广泛存在于真核细胞中的生命现象,它是生命体特殊的分解代谢途径,控制着细胞内蛋白质和细胞器的降解,对维持细胞生存及稳态有重要作用。现如今已成为生物医学领域的研究热点,研究发现自噬与许多疾病有关。目前,缺血性脑卒中是造成人类死亡和残疾的主要疾病之一,在治疗过程中引起的脑缺血再灌注损伤尤为普遍,受到越来越多学者的关注。该文对自噬及其在脑缺血再灌注损伤中的作用机制进行阐述,为进一步治疗缺血性脑血管疾病提供理论依据。

Autophagy is a life phenomenon widely existing in eukaryotic cells and a special metabolic pathway of decomposition. It controls the degradation of protein and organelles and is essential for cell survival and tissue homeostasis. At present,autophagy has become a hot research topic in the field of biological medicine,and the studies have demonstrated the association with various diseases. To date,ischemic cerebral stroke responsible for human death and disability may cause the ischemia-reperfusion（I/R） injury,which is common and receives much more concern. This review states autophagy and its mechanisms on the I/R injury to provide the theoretical basis for further therapy on ischemic cerebrovascular disorder.