冠心病患者糖化血红蛋白、纤维蛋白原与B型脑钠肽检测的临床意义

The clinical significance of glycosylated hemoglobin、fibrinogen and B-type brain natriuretic eptide in coronary heart disease patients

目的:探究冠心病患者糖化血红蛋白(Hb A1c)、纤维蛋白原(FIB)与B型脑钠肽(BNP)检测的临床意义。方法:选取收治的冠心病患者134例,分为单纯冠心病组和冠心病合并糖尿病组,同时纳入68例同期健康体检者作为对照组,分别检测和比较各组Hb A1c、FIB和BNP水平的差异。结果:冠心病患者组的Hb A1c、BNP和FIB显著高于健康对照组,且各项指标的差异有统计学意义(P<0.05);冠心病并糖尿病患者组的Hb A1c、FIB高于单纯冠心病患者组,但差异无统计学意义,而冠心病并糖尿病患者组BNP显著高于单纯冠心病患者组,差异有统计学意义(P<0.05)。结论:糖化血红蛋白、纤维蛋白原和B型脑纳肽与冠心病皆有一定的相关性,并可对心血管事件的发生进行预测。

Objective To explore the clinical significance of glycosylated hemoglobin（Hb A1c）,fibrinogen（FIB） and B-type brain natriuretic eptide（BNP） in patients with Coronary Heart Disease（CHD）. Method A total of 134 patients were seleted and diveded into CHD group（n = 66） and CHD with diabetes mellitus group（n = 68）. In addition,68 healthy check-ups were selected as control group. Hb A1c、FIB and BNP were measured in all groups. Results The levels of Hb A1c、FIB and BNP of CHD group were signifiantly higher than that of control group（ P〈0. 05）,the levels of BNP of CHD with diabetes mellitus group were signifiantly higher than that of CHD group（ P〈0. 05）. As for Hb A1 and FIB,there was no difference between CHD group and CHD with diabetes mellitus group. Conclusion The levels of Hb A1c、FIB and BNP are closely correlated with the severity in CHD patients and the detection of them can predict the prevalence of cardiovascular events.