针刺配合帕罗西汀治疗肝气郁结型抑郁症临床观察

Clinical Observation of Acupuncture plus Paroxetine for Depression Due to Liver-qi Stagnation

目的通过观察针刺配合帕罗西汀治疗肝气郁结型抑郁症的临床疗效,为肝气郁结型抑郁症探索更为有效的治疗方法。方法将60例肝气郁结型抑郁症患者随机分成两组,治疗组和对照组各30例,治疗组采用针刺配合帕罗西汀治疗,对照组单纯服用帕罗西汀,连续治疗8星期,治疗前后以汉密尔顿抑郁量表(HAMD)、中医证候量表和中枢性神经递质检测作为观察指标,评定疗效结果。结果治疗组总有效率为96.6%,对照组总有效率为71.4%,治疗组明显优于对照组(P<0.05)。在中医证候方面、5-HT浓度方面,治疗组都明显优于对照组(P<0.01)。结论针刺配合帕罗西汀是临床治疗肝气郁结型抑郁症的一种有效可行的方法。

Objective To observe the clinical efficacy of acupuncture plus Paroxetine in treating depression due to liver-qi stagnation, for seeking a more effective treatment for this disease. Method Sixty patients with depression due to liver-qi stagnation were randomized into a treatment group and a control group, 30 cases in each group. The treatment group was intervened by acupuncture plus Paroxetine, while the control group was by Paroxetine alone, successively for 8 weeks. Hamilton Depression Scale （HAMD）, Chinese medicine syndrome and sign score, and central neurotransmitters were observed before and after the treatment, for evaluating the therapeutic efficacy. Result The total effective rate was 96.6% in the treatment group versus 71.4% in the control group, and the treatment group was superior to the control group （P〈0.05）. Conclusion Acupuncture plus Paroxetine is an effective method in treating depression due to liver-qi stagnation.