常规药物和舌下免疫治疗变应性鼻炎的疗效分析

Analysis of therapeutic effect of conventional drugs and sublingual immunotherapy on allergic rhinitis

目的 探讨常规药物和舌下免疫治疗变应性鼻炎的疗效。方法 选取我院2013年6月-2014年6月收治的变应性鼻炎患者60例,依据治疗方法将这些患者分为个体化规范化的舌下免疫治疗组（n=30）和常规药物治疗组（n=30）两组,对两组患者的临床症状评分、临床疗效、不良反应发生情况进行统计分析。结果 舌下免疫治疗组患者的鼻塞、鼻涕、鼻痒、喷嚏评分及总分均显著低于常规治疗组（P〈0.05）,治疗总有效率[86.7%（26/30）]显著高于常规药物治疗组[43.3%（13/30）]（P〈0.05）,但两组患者不良反应发生率之间差异不显著[10.0%（3/30）、6.7%（2/30）,P〉0.05]。结论变应性鼻炎的个体化规范化的舌下免疫治疗效果较常规药物治疗好,值得在临床推广使用。

Objective To compare the efficacy of conventional drugs and sublingual immunotherapy on allergic rhinitis. Methods A total of 60 patients with allergic rhinitis from June 2013 to June 2014 in our hospital were enrolled and divided into individualized and standardized sublingual immunotherapy group（n=30）, conventional drug treatment group （n=30） according to the treatment method. The clinical symptom score, clinical efficacy and adverse events in the two groups were statistically analyzed. Results The scores of nasal congestion, nasal discharge, nasal itching, sneezing and the total score of these above in sublingual immunotherapy group were significantly lower than those of routine treatment group（P〈0.05）. The total effective rate was 86.7%（26/30）, which was significantly higher than that of the conventional drug treatment group（43.3%, 13/30）（P〈0.05）. However, there was no significant difference between the two groups in the incidence of adverse reactions[（10.0%, 3/30）, 6.7% （2/30） （P〉0.05）]. Conclusion Individualized normalized sublingual immunotherapy of allergic rhinitis is more effective than conventional drug therapy and worthy of clinical application.