吡格列酮联合格列齐特缓释片治疗早期2型糖尿病的临床疗效观察

Efficacy of pioglitazone combined with gliclazide sustained-release tablets in type 2 diabetes mellitus on early stage

目的观察吡格列酮联合格列齐特缓释片治疗早期2型糖尿病患者中的临床疗效。方法选取2013年6月～2016年7月期间浙江省台州市天台县中医院收治的80例早期2型糖尿病患者为研究对象,将患者根据随机数字表法分为2组,每组各40例。对照组采用格列齐特缓释片进行治疗,观察组采用吡格列酮联合格列齐特缓释片进行治疗。检测与比较2组患者治疗前后的血糖水平、糖化血红蛋白水平、脂代谢指标及胰岛功能指标。结果治疗前2组患者的血糖水平、糖化血红蛋白水平、脂代谢指标及胰岛功能指标比较,差异有统计学意义（P〈0.05）,而治疗后2组的血糖水平、糖化血红蛋白水平、脂代谢指标及胰岛功能指标均持续改善,且观察组的血糖水平、糖化血红蛋白水平均低于对照组,脂代谢指标及胰岛功能指标均好于对照组,差异有统计学意义（P〈0.05）。结论吡格列酮联合格列齐特缓释片治疗早期2型糖尿病患者中的临床疗效较好,对于血糖、血脂及胰岛功能状态均有积极的调节作用。

Objective To observe the clinical effect of pioglitazone combined with gliclazide sustained-release tablets in the treatment of patients with early type 2 diabetes mellitus.Methods 80 patients with early type 2 diabetes mellitus in our hospital from June 2013 to July 2016 were selected as the study object,and the patients were randomly divided into two groups,40 cases in each group.The control group were treated with gliclazide sustained-release tablets,the observation group were treated with pioglitazone combined with gliclazide sustained-release tablets.Then the blood glucose level,glycosylated hemoglobin level,lipid metabolism indexes and islet function indexes of two groups before and after the treatment were detected and compared.Results The blood glucose level,glycosylated hemoglobin level,lipid metabolism indexes and islet function indexes of two groups before the treatment were compared,the difference was statistically significant（P〈0.05）,while the blood glucose level,glycosylated hemoglobin level,lipid metabolism indexes and islet function indexes of two groups after the treatment were continuously improved,and the blood glucose level and glycosylated hemoglobin level of observation group were lower than those of control group,the ipid metabolism indexes and islet function indexes were all better than those of control group,the difference was statistically significant（P〈0.05）.Conclusion The clinical effect of pioglitazone combined with gliclazide sustained-release tablets in the treatment of patients with early type 2 diabetes mellitus is better,and it also has active adjustion role for the blood glucose,blood lipid and islet function state.