视神经脊髓炎与血脑屏障

Neuromyelitis optica and blood brain barrier

视神经脊髓炎(NMO)是一种主要累及视神经和脊髓的炎性脱髓鞘疾病,既往认为是多发性硬化的特殊亚型,随着NMO患者血清中特异性抗体NMO-IgG及其作用靶点的发现,NMO成为一个独立的疾病实体而不同于多发性硬化。近年的研究显示,NMO-IgG产生于血液循环,只有在血脑屏障破坏的前提下才能进入中枢神经系统发挥其致病作用,可见血脑屏障的破坏在NMO疾病的发生发展过程中具有重要意义。

Neuromyelitis optica（NMO）is a major disease involving the optic nerve and spinal cord inflammatory demyelinating. Previously it was thought a special subtype of multiple sclerosis. With the discovery of specific antibody NMO-Ig G in NMO patients serum and its action target point,NMO becomes an independent disease entity which is different from multiple sclerosis. Recent studies have shown that NMOIg G is produced in the peripheral blood,only when the blood brain barrier damage can it enter the central nervous system to play a role in the disease pathogenesis. It has important significance of the blood brain barrier damage in the occurrence and development of NMO disease.