功能康复训练联合盐酸多奈哌齐对轻中度帕金森病痴呆患者神经系统功能及康复的影响

Effect of rehabilitation training combined with donepezil hydrochloride on the function and rehabilitation of nervous system in patients with mild and moderate Parkinson's disease dementia

目的探讨功能康复训练联合盐酸多奈哌齐对轻中度帕金森病痴呆(PDD)患者神经系统功能及康复进程的影响。方法选取我院2012-01—2015-01收治入院的帕金森病(PD)合并轻中度痴呆患者100例为研究对象,按随机数字表法分为2组各50例,对照组采用盐酸多奈哌齐治疗,观察组在此基础上给予认知功能康复训练,2组均于治疗前和治疗第4、8、12周时采用蒙特利尔认知评估量表(MoCA)评估其认知功能,同时采用统一帕金森病评分量表(UPDRS)评估PD的严重程度。结果观察组总有效率明显高于对照组,差异有统计学意义(P<0.05);2组治疗后MoCA、精神、行为和情绪评分、运动检查评分与组内治疗前比较差异均有统计学意义(P<0.05);观察组治疗后MoCA、精神、行为和情绪评分、运动检查评分与对照组治疗后比较差异均有统计学意义(P<0.05)。结论功能康复训练联合盐酸多奈哌齐治疗对PDD有效,且起效更快。

Objective To investigate the effects of functional rehabilitation training combined with donepezil on nervous system function and rehabilitation process in mild and moderate Parkinson’s disease with dementia（PDD）patients .Methods One hundred cases of mild and moderate dementia patients in our hospital from January 2012 to 2015 January were selected as＆amp;nbsp;the research objects ,and were divided into two groups according to the random number table method ,50 cases in each group . The control group was treated with donepezil hydrochloride ;observation group was given cognitive rehabilitation training group on the basis of control group .Montreal Cognitive Assessment Scale（MoCA）was used to assess the cognitive function before treatment and after treatment of 4 ,8 and 12 weeks .At the same time ,the Unified Parkinson＆#39;s Disease Rating Scale（UPDRS） was used to assess the severity of PD patients .Results The clinical total effective rate was significantly higher in the observa‐tion group than that in the control group ,and the difference was statistically significant （P〈0.05）;MoCA ,spirit ,behavior and mood score ,exercise test score in the two groups after treatment were statistically significant than those before treatment （P〈0.05）;MoCA ,spirit ,behavior and mood score ,exercise test score in observation group after treatment were statistically signifi‐cant compared to the control group（P〈0.05） .Conclusion Rehabilitation training combined with donepezil in the treatment of PDD is effective and faster .