七氟烷和丙泊酚麻醉对老年结直肠癌患者认知功能的影响

Effect of Sevoflurane and Propofol Anaesthesia on the Awareness Function of Senile Patients with Colorectal Cancer

目的探讨七氟烷和丙泊酚麻醉对老年结直肠癌患者认知功能的影响。方法选取2014年6月—2015年6月该院外一科收治的老年结直肠癌患者100例,随机分成两组,每组50例,其中一组患者在手术诱导麻醉后采用静滴丙泊酚维持麻醉,作为B组,对另一组患者在手术诱导麻醉后采用呼吸面罩持续吸入七氟烷维持麻醉,作为Q组,比较两组患者术后的MMSE评分状况以及手术满意度情况。结果麻醉前两组评分差异无统计学意义(P>0.05),麻醉后1、6、12 h,Q组评分明显低于B组(P<0.05),麻醉后24 h两组均与治疗前差异不大(P>0.05);Q组不良反应发生率8.0%,明显低于B组30.0%(P<0.05)。结论吸入七氟烷以及静滴丙泊酚维持麻醉产生的认知功能障碍以七氟烷症状较重,但均为可逆的,且七氟烷维持麻醉不良反应要少,更加可靠。

Objective To study the effect of sevoflurane and propofol anaesthesia on the awareness function of senile patients with colorectal cancer. Methods 100 cases of senile patients with colorectal cancer admitted and treated in the first department of surgery in our hospital from June 2014 to June 2015 were selected and randomly divided into two groups with50 cases in each, the group B adopted the intravenous infusion of propofol for maintaining anaesthesia after the operation induced anesthesia, the group Q adopted the continuous inhalation of sevoflurane by respiration mask after the operation induced anesthesia, and the MMSE score situation after operation and operation satisfactory degree of the two groups were compared. Results The difference in score between the two groups was not obvious before anaesthesia（P〉0.05）, and the score in the group Q was obviously lower than that in the group B at 1h, 6 h and 12 h after anaesthesia（P〈0.05）, and the difference at 24 h after anaesthesia was not big compared with that before treatment（P〉0.05）, and the incidence rate of adverse reactions in the group Q was obviously lower than that in the group B（8.0% vs 30.0%）（P〈0.05）. Conclusion Compared with the inhalation of sevoflurane, the intravenous infusion of propofol can lead to more serious cognitive function disorder,but both are reversible, and the adverse reaction of sevoflurane for maintaining anaesthesia is fewer and it is more reliable.