灯盏花素和丹参注射液治疗冠心病心绞痛患者有效性及安全性的Meta分析

Effectiveness and safety of Dengzhanhuasu and Dansheng Injection in treatment of patients with angina pectoris of coronary heart disease:A Meta-analysis

目的:应用Meta分析方法对比灯盏花素与丹参注射液治疗冠心病心绞痛患者的有效性及安全性,为临床用药提供依据。方法:计算机检索Cochrane试验资料库、Ovid-Medline全文数据库、EMBase数据库、PubMed数据库、中国学术文献总库(CNKI)、万方数字化期刊库,维普数据库(VIP)及中国生物医学文献数据库(CBM),获得有关灯盏花素和丹参注射液治疗冠心病心绞痛患者有效性及安全性的文献,根据入选与剔除原则筛选文献、评价文献质量,提取相关数据,应用RevMan 5.3软件进行Meta分析。结果:初步检索出167篇文献,根据选取标准共8篇有关灯盏花素和丹参注射液治疗冠心病心绞痛的随机对照研究符合入选标准。缓解症状疗效分析,χ~2=2.62,df=7,P=0.92,Z=6.85,95%CI:2.73~6.10;心电图疗效分析,χ~2=6.37,df=7,P=0.50,Z=6.37(P=0.000 01),95%CI:1.94~3.49。2种药物治疗冠心病心绞痛均无明显不良反应。Meta分析,灯盏花素和丹参注射液治疗冠心病心绞痛患者在缓解症状及改善心电图疗效方面比较差异有统计学意义(P<0.05)。结论:与丹参注射液比较,灯盏花素治疗冠心病心绞痛具有更好的疗效,且二者均无明显不良反应。

Objective：To compare the effectiveness and safety of Dengzhanhuasu and Danshen Injection in the treatment of the patients with angina pectoris of coronary heart disease with Meta-analysis,and to provide basis for their application in clinic.Methods：Computer search was performed using Cochrane Central Register of Controlled Trial,Ovid-medline,EMBASE,PubMed,CNKI, Wanfang,VIP and CBM,and the literatures about the effectiveness and safety of Dengzhanhuasu and Dansheng Injection in the treatment of the patients with angina pectonis of coronary heart disease were obtained.According to the principle of selection and elimination,the literatures were selected,and the qualities of literatures were evaluated.The related data were extracted from the literatures.RevMan 5.3software was used to extract the data for Meta-analysis.Results：A total of 167 literatures were retrieved,and 8randomlized-controlled studies were selected according to the selection criteria.The evaluation results of the effectiveness of angina pectoris according to symptom showed thatχ^2=2.62,df=7,P=0.92,Z=6.85（P〈0.000 01）,95%CI：2.73-6.10.The evaluation of the effectiveness of angina pectoris according to electrocardiogram,χ^2=6.37,df=7,P=0.50,Z=6.37（P=0.000 01）,95%CI：1.94-3.49.The results of Meta-analysis showed that there were significant differences in the relief of symptoms and improvement of the electrocardiogram efficacy between Dengzhanhuasu and Danshen Injection in the treatment of angina pectoris of coronary heart disease（P〈0.05）.Conclusion：Dengzhanhuasu has better effectiveness in the treatment of the patients with unstable angina than Dansheng Injection and they have the same safety.