胆汁酸转运蛋白的研究进展

Research Progress of Bile Acid Transporters

胆汁酸参与调节人体多种生理功能,位于肝脏和小肠的转运蛋白在维持胆汁酸肠肝循环和稳态平衡中发挥着重要作用。近年来随着分子生物学技术的飞速发展,胆汁酸转运蛋白的克隆鉴定及其复杂调控机制的阐明取得了巨大成果。胆汁酸转运蛋白受胆汁酸、核受体、转录因子、激素等多因素的调控,影响其蛋白表达、细胞定位和转运活性,从而与某些胆汁酸代谢紊乱性疾病密切相关。笔者综述了主要胆汁酸转运蛋白的研究进展,以期为胆汁酸转运蛋白相关联的疾病机制研究与药物研发提供有价值的参考。

Bile acids participated in regulation of many physiological functions in the human body. Transporters in liver and intesti- nal play an important role in maintaining the enterohepatic circulation and bile acid homeostasis. With the rapid development of molec- ular biology in recent years, there has been great progress toward cloning and identifying the individual bile acid transporters and ex- plaining their complex regulation. Bile acid transporters were regulated by various factors including bile acids, nuclear receptors, tran- scription factors, hormones, etc. , which influence their protein expression, cell location and transport activities. This article reviews the research progress of bile acid transporters for the purpose of providing references for the mechanism research of bile acid transporter related disorders and drug development .